The RMI1 Polyclonal Antibody (CAB4991) is a crucial tool for researchers studying the RMI1 protein, which is involved in DNA repair and genomic stability maintenance. This antibody, generated in rabbits, exhibits high specificity and sensitivity towards human samples, making it ideal for Western blot analysis.The RMI1 protein is known to interact with the BLM helicase and topoisomerase III alpha, forming the BTR complex that plays a critical role in resolving DNA structures during replication and recombination.
Dysregulation of RMI1 has been linked to genomic instability, predisposing cells to DNA damage and mutations.By using the RMI1 Polyclonal Antibody, researchers can detect and analyze the expression of RMI1 in different cell types, providing insights into its function in DNA repair pathways. This antibody is a valuable tool for studies in cancer research, as well as understanding the mechanisms underlying genetic diseases and response to DNA-damaging agents.
Product Name:
RMI1 Rabbit Polyclonal Antibody
SKU:
CAB4991
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-350 of human RMI1 (NP_079221.2).
Predicted to enable nucleotide binding activity. Predicted to be involved in double-strand break repair via homologous recombination and resolution of meiotic recombination intermediates. Predicted to act upstream of or within glucose homeostasis; reduction of food intake in response to dietary excess; and response to glucose. Located in nuclear body.
Purification Method:
Affinity purification
Gene ID:
80010
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using RMI1 Antibody (CAB4991) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 90s.
