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Anti-RMI1 Antibody (CAB4991)

SKU:
CAB4991
Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Mouse
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
RMI1
BLAP75
C9orf76
FAAP75
Research Area:
Epigenetics and Nuclear Signaling
  • Epigenetics and Nuclear Signaling Antibodies 3 Anti-RMI1 Antibody CAB4991
  • Epigenetics and Nuclear Signaling Antibodies 3 Anti-RMI1 Antibody CAB4991
€139 - €419
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Description

Product Name:RMI1 Rabbit pAb
Product Code:CAB4991
Size:20uL, 50uL, 100uL
Synonyms:RMI1, BLAP75, C9orf76, FAAP75
Applications:WB
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-350 of human RMI1 (NP_079221.2).
Applications:WB
Recommended Dilutions:WB 1:200 - 1:2000
Reactivity:Human, Mouse
Positive Samples:HeLa, Mouse liver
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-350 of human RMI1 (NP_079221.2).
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MNVT SIAL RAET WLLA AWHV KVPP MWLE ACIN WIQE ENNN VNLS QAQM NKQV FEQW LLTD LRDL EHPL LPDG ILEI PKGE LNGF YALQ INSL VDVS QPAY SQIQ KLRG KNTT NDLV TAEA QVTP KPWE AKPS RMLM LQLT DGIV QIQG MEYQ PIPI LHSD LPPG TKIL IYGN ISFR LGVL LLKP ENVK VLGG EVDA LLEE YAQE KVLA RLIG EPDL VVSV IPNN SNEN IPRV TDVL DPAL GPSD EELL ASLD ENDE LTAN NDTS SERC FTTG SSSN TIPT RQSS FEPE FVIS PRPK EEPS NLSI HVMD GELD DFSL EEAL LLEE TVQK EQME TKEL QPLT FNRN ADRS IE
Gene ID:80010
Uniprot:Q9H9A7
Cellular Location:Nucleus
Calculated MW:70kDa
Observed MW:75kDa
UniProt Protein Function:RMI1: Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates to limit DNA crossover formation in cells. Promotes TOP3A binding to double Holliday junctions (DHJ) and hence stimulates TOP3A-mediated dissolution. Required for BLM phosphorylation during mitosis. Within the BLM complex, required for BLM and TOP3A stability. Belongs to the RMI1 family.
UniProt Protein Details:

Protein type:DNA repair, damage

Chromosomal Location of Human Ortholog: 9q21.32

Cellular Component: nucleoplasm; nucleus

Molecular Function:protein binding

Biological Process: multicellular organism growth; response to glucose stimulus; DNA replication; glucose homeostasis; reduction of food intake in response to dietary excess

NCBI Summary:RMI1 is a component of protein complexes that limit DNA crossover formation via the dissolution of double Holliday junctions (Raynard et al., 2006 [PubMed 16595695]).[supplied by OMIM, Mar 2008]
UniProt Code:Q9H9A7
NCBI GenInfo Identifier:322510109
NCBI Gene ID:80010
NCBI Accession:Q9H9A7.3
UniProt Secondary Accession:Q9H9A7,Q05BX1, Q05CW3, Q5SQG8, Q5SQG9, Q6P1Q4, Q6PI89 Q7Z6L6,
UniProt Related Accession:Q9H9A7
Molecular Weight:625
NCBI Full Name:RecQ-mediated genome instability protein 1
NCBI Synonym Full Names:RecQ mediated genome instability 1
NCBI Official Symbol:RMI1  
NCBI Official Synonym Symbols:BLAP75; FAAP75; C9orf76  
NCBI Protein Information:recQ-mediated genome instability protein 1; BLM-associated protein 75 kDa; BLM-associated polypeptide, 75 kDa; RMI1, RecQ mediated genome instability 1, homolog; homolog of yeast RecQ-mediated genome instability 1 (RMI1)
UniProt Protein Name:RecQ-mediated genome instability protein 1
UniProt Synonym Protein Names:BLM-associated protein of 75 kDa; BLAP75; FAAP75
Protein Family:RecQ-mediated genome instability protein
UniProt Gene Name:RMI1  
UniProt Entry Name:RMI1_HUMAN

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