The RNASEH2C Antibody (CAB13884) is a high-quality antibody developed for reliable detection and analysis of target proteins. This antibody, produced in rabbits, exhibits high specificity and sensitivity towards human samples, making it ideal for use in Western blot applications. By binding to the RNASEH2C protein, this antibody enables accurate detection and analysis of RNASEH2C expression in a variety of cell types.RNASEH2C plays a crucial role in maintaining genomic stability by removing RNA primers during DNA replication. Dysregulation of RNASEH2C has been linked to various human diseases, including Aicardi-Goutières Syndrome and systemic lupus erythematosus.
This antibody is validated for use in WB, ELISA applications and has demonstrated reactivity against Human samples.
Product Name:
RNASEH2C Antibody
SKU:
CAB13884
Size:
20μL, 100μL
Reactivity:
Human
Conjugate:
Unconjugated
Immunogen:
Recombinant protein (or fragment).This information is considered to be commercially sensitive.
Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Synonyms:
AGS3, AYP1, RNASEH2C
Positive Sample:
293T, HeLa
Cellular Localization:
Nucleus.
Calculated MW:
18kDa
Observed MW:
20kDa
This gene encodes a ribonuclease H subunit that can cleave ribonucleotides from RNA:DNA duplexes. Mutations in this gene cause Aicardi-Goutieres syndrome-3, a disease that causes severe neurologic dysfunction. A pseudogene for this gene has been identified on chromosome Y, near the sex determining region Y (SRY) gene.
Purification Method
Affinity purification
Gene ID
84153
RRID
AB_2760737
Buffer Information
Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using RNASEH2C Rabbit pAb (CAB13884) at 1:3000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (AbGn00021). Exposure time: 90s.
