The RRAD Polyclonal Antibody (PAC018859) is a valuable tool for researchers studying the Ras-related associated with diabetes (RRAD) protein. This antibody, generated in rabbits, demonstrates high reactivity with human samples and is specifically validated for use in Western blot applications. By targeting the RRAD protein, this antibody allows for accurate detection and analysis in a variety of cell types, making it ideal for investigations in diabetes research and related fields.RRAD is a member of the Ras superfamily of small GTPases and has been implicated in the regulation of glucose and lipid metabolism.
Its role in insulin signaling and glucose uptake makes it a significant target for research on metabolic disorders such as diabetes and obesity. Understanding the function and regulation of RRAD is crucial for developing therapies that target this pathway for the treatment of metabolic diseases. The RRAD Polyclonal Antibody provides a reliable tool for studying the role of RRAD in cellular signaling and metabolic pathways.
Antibody Name:
RRAD Antibody (PACO18859)
Antibody SKU:
PACO18859
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:1000-1:5000, IHC:1:25-1:100
Species Reactivity:
Human, Mouse, Rat
Immunogen:
Synthetic peptide of human RRAD
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using PACO18859(RRAD Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: x200).
The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using PACO18859(RRAD Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
The protein may be important in cardiac antiarrhythmia via the strong suppression of voltage-gated L-type Ca2+ currents. As regulator of voltage-dependent L-type calcium channel subunit alpha-1C trafficking to the cell membrane. Inhibits cardiac hypertrophy through the calmodulin-dependent kinase II (CaMKII) pathway and phosphorylation and activation of CAMK2D. Mostly expressed in the heart and muscle of type II diabetic humans. Also found in the skeletal muscle, lung and adipose tissue. Lesser amounts in placenta and kidney.
Synonyms:
Ras-related associated with diabetes
UniProt Protein Function:
RRAD: a small G protein of the RGK family. May play an important role in cardiac antiarrhythmia via the strong suppression of voltage-gated L-type Ca(2+) currents. Regulates voltage-dependent L-type calcium channel subunit alpha- 1C trafficking to the cell membrane. Inhibits cardiac hypertrophy through the calmodulin-dependent kinase II (CaMKII) pathway. Interacts with calmodulin preferentially in the inactive, GDP-bound form. Interacts with CAMK2D and CACNB2. Interaction with CACNB2 regulates the trafficking of CACNA1C to the cell membrane. Most abundantly expressed in the heart. Also found in the skeletal muscle and lung. Lesser amounts in placenta and kidney. Also detected in adipose tissue. Overexpressed in muscle of type II diabetic humans.Protein type: G protein, monomeric, RGK; G protein; G protein, monomericChromosomal Location of Human Ortholog: 16q22Cellular Component: plasma membraneMolecular Function: calmodulin binding; GTPase activity; protein binding; GTP bindingBiological Process: metabolic process; small GTPase mediated signal transduction
