The RRAD Polyclonal Antibody (PAC018860) is a valuable tool for researchers studying RRAD, a protein involved in cellular processes such as glucose metabolism and insulin signaling. This antibody, produced in rabbits, shows high specificity and reactivity with human samples, making it a reliable choice for Western blot applications.RRAD, a member of the Ras superfamily of small GTPases, plays a role in regulating glucose uptake and energy metabolism in cells. Dysregulation of RRAD has been linked to conditions such as insulin resistance and type 2 diabetes, making it a key target for research in metabolic disorders.
By detecting and analyzing RRAD protein levels in various cell types, this antibody enables researchers to further understand the function and dysregulation of RRAD in metabolic diseases. Its use in immunology and cancer research may provide insights into potential therapeutic strategies targeting RRAD in the future.
Antibody Name:
RRAD Antibody (PACO18860)
Antibody SKU:
PACO18860
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:5000, IHC:1:50-1:200
Species Reactivity:
Human, Mouse, Rat
Immunogen:
Synthetic peptide of human RRAD
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using PACO18860(RRAD Antibody) at dilution 1/50, on the right is treated with synthetic peptide. (Original magnification: x200).
The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using PACO18860(RRAD Antibody) at dilution 1/50, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
The protein may be important in cardiac antiarrhythmia via the strong suppression of voltage-gated L-type Ca2+ currents. As regulator of voltage-dependent L-type calcium channel subunit alpha-1C trafficking to the cell membrane. Inhibits cardiac hypertrophy through the calmodulin-dependent kinase II (CaMKII) pathway and phosphorylation and activation of CAMK2D. Mostly expressed in the heart and muscle of type II diabetic humans. Also found in the skeletal muscle, lung and adipose tissue. Lesser amounts in placenta and kidney.
Synonyms:
Ras-related associated with diabetes
UniProt Protein Function:
RRAD: a small G protein of the RGK family. May play an important role in cardiac antiarrhythmia via the strong suppression of voltage-gated L-type Ca(2+) currents. Regulates voltage-dependent L-type calcium channel subunit alpha- 1C trafficking to the cell membrane. Inhibits cardiac hypertrophy through the calmodulin-dependent kinase II (CaMKII) pathway. Interacts with calmodulin preferentially in the inactive, GDP-bound form. Interacts with CAMK2D and CACNB2. Interaction with CACNB2 regulates the trafficking of CACNA1C to the cell membrane. Most abundantly expressed in the heart. Also found in the skeletal muscle and lung. Lesser amounts in placenta and kidney. Also detected in adipose tissue. Overexpressed in muscle of type II diabetic humans.Protein type: G protein, monomeric, RGK; G protein; G protein, monomericChromosomal Location of Human Ortholog: 16q22Cellular Component: plasma membraneMolecular Function: calmodulin binding; GTPase activity; protein binding; GTP bindingBiological Process: metabolic process; small GTPase mediated signal transduction
