Description
SEMA3G Antibody (PACO14974)
The SEMA3G Polyclonal Antibody (PACO14974) is a valuable tool for research involving SEMA3G, a protein that plays a key role in immune regulation and cancer progression. This antibody, generated in rabbits, demonstrates high specificity and sensitivity when detecting SEMA3G in human samples, making it an ideal choice for Western blot applications.SEMA3G is a member of the semaphorin family, known for their involvement in cell signaling and immune responses. SEMA3G has been implicated in inhibiting tumor growth and metastasis in various cancers, making it a promising target for cancer research and therapy development. By targeting SEMA3G with this antibody, researchers can better understand its mechanisms of action and potential therapeutic applications in cancer treatment.
Furthermore, SEMA3G is also involved in immune regulation, suggesting its role in modulating inflammatory responses and potentially autoimmune disorders. By studying the expression and function of SEMA3G using this antibody, researchers can gain insights into its impact on immune homeostasis and explore its therapeutic potential in various immune-related diseases.Overall, the SEMA3G Polyclonal Antibody (PACO14974) is a valuable tool for researchers interested in studying SEMA3G's roles in cancer progression and immune regulation, offering reliable and accurate detection of this important protein in human samples.
| Antibody Name: | SEMA3G Antibody (PACO14974) |
| Antibody SKU: | PACO14974 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:1000-1:5000, IHC:1:25-1:100 |
| Species Reactivity: | Human |
| Immunogen: | Fusion protein of human SEMA3G |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using PACO14974(SEMA3G Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: x200). |
| Background: | Semaphorins are a class of secreted and membrane proteins that act as axonal growth cone guidance molecules. They primarily act as short-range inhibitory signals and signal through multimeric receptor complexes. They are usually cues to deflect axons from inappropriate regions, especially important in neural system development. The major class of proteins that act as their receptors are called plexins.SEMA3G possesses anti-migration and anti-invasion ability. SEMA3G inhibited tumor cell migration and invasion, which may be obtained through cell autonomous or paracrine mechanisms, and SEMA3G is a potential target for antitumor migration and invasion. |
| Synonyms: | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3G |
| UniProt Protein Function: | SEMA3G: a secreted protein that has chemorepulsive activities for sympathetic axons. A high-affinity ligand of NRP2. |
| UniProt Protein Details: | Protein type:Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: 3p21.1 Cellular Component: membrane Molecular Function:receptor activity Biological Process: multicellular organismal development |
| NCBI Summary: | The transcription of this gene is activated by PPAR-gamma, and the resulting protein product plays a role in endothelial cell migration. Expression of this gene also inhibits tumor cell migration and invasion. [provided by RefSeq, Jul 2016] |
| UniProt Code: | Q9NS98 |
| NCBI GenInfo Identifier: | 74761676 |
| NCBI Gene ID: | 56920 |
| NCBI Accession: | Q9NS98.1 |
| UniProt Related Accession: | Q9NS98 |
| Molecular Weight: | |
| NCBI Full Name: | Semaphorin-3G |
| NCBI Synonym Full Names: | semaphorin 3G |
| NCBI Official Symbol: | SEMA3GÂ Â |
| NCBI Official Synonym Symbols: | sem2Â Â |
| NCBI Protein Information: | semaphorin-3G |
| UniProt Protein Name: | Semaphorin-3G |
| UniProt Synonym Protein Names: | Semaphorin sem2 |
| Protein Family: | Semaphorin |
| UniProt Gene Name: | SEMA3GÂ Â |
| UniProt Entry Name: | SEM3G_HUMAN |
