The SEMA6A Polyclonal Antibody (PAC020421) is a valuable tool for researchers studying SEMA6A, a cell surface protein involved in neuronal development and axon guidance. This antibody, produced in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications. It specifically binds to the SEMA6A protein, allowing for precise detection and analysis in various cell types commonly used in neurobiology and developmental biology research.SEMA6A, a member of the semaphorin family, is crucial for proper neuronal circuit formation and synapse development.
Its role in guiding axons and regulating neuronal connectivity makes it a key target for studying neurological disorders and understanding brain development. By investigating the function of SEMA6A, researchers can gain insights into conditions such as autism, schizophrenia, and neurodevelopmental disorders, leading to potential therapeutic advancements in neurology and neuroscience.
Antibody Name:
SEMA6A Antibody (PACO20421)
Antibody SKU:
PACO20421
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:1000-1:2000, IHC:1:25-1:100
Species Reactivity:
Human, Mouse
Immunogen:
Synthetic peptide of human SEMA6A
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO20421(SEMA6A Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
The transmembrane semaphorin SEMA6A is expressed in developing neural tissue and is required for proper development of the thalamocortical projection. Cell surface receptor for PLXNA2 that plays an important role in cell-cell signaling. Required for normal granule cell migration in the developing cerebellum. Promotes reorganization of the actin cytoskeleton and plays an important role in axon guidance in the developing central nervous system.
Synonyms:
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
UniProt Protein Function:
SEMA6A: a single-pass type I membrane protein of the semaphorin family that can act as repulsive axon guidance cues. May play a role in channeling sympathetic axons into the sympathetic chains and controlling the temporal sequence of sympathetic target innervation. Active as a homodimer or oligomer. Interacts with EVL. Two isoforms of the human protein are produced by alternative splicing.Protein type: Cell adhesion; Membrane protein, integralChromosomal Location of Human Ortholog: 5q23.1Cellular Component: integral to plasma membraneMolecular Function: chemorepellent activity; protein binding; semaphorin receptor bindingBiological Process: negative regulation of axon extension involved in axon guidance; neural crest cell migration
UniProt Protein Details:
NCBI Summary:
The transmembrane semaphorin SEMA6A is expressed in developing neural tissue and is required for proper development of the thalamocortical projection (Leighton et al., 2001 [PubMed 11242070]).[supplied by OMIM, Feb 2011]
