Description
SENP5 Antibody (PACO01481)
The SENP5 Polyclonal Antibody (PACO01481) is a valuable tool for researchers studying SENP5, a protein involved in post-translational modification and regulation of various cellular processes. This antibody, raised in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications. By binding specifically to SENP5, researchers can easily detect and analyze this protein in a variety of cell types, making it an ideal choice for studies in molecular biology and cancer research.SENP5, a SUMO-specific protease, plays a crucial role in the regulation of protein function through modification. Its involvement in processes such as DNA repair, cell cycle regulation, and gene transcription highlights its significance in cellular physiology and disease development.
Research on SENP5 can provide insights into the mechanisms underlying cancer progression, neurodegenerative disorders, and other diseases where dysregulation of protein modification is implicated.By utilizing the SENP5 Polyclonal Antibody, researchers can uncover the intricate functions of SENP5 and its implications in various disease contexts. This antibody serves as a valuable tool for exploring the role of SENP5 in cellular pathways and may pave the way for novel therapeutic approaches targeting protein modification in disease treatment.
| Antibody Name: | SENP5 Antibody |
| Antibody SKU: | PACO01481 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC |
| Recommended Dilutions: | WB:1:500-1:2000, IHC:1:100-1:300 |
| Species Reactivity: | Human, Mouse, Monkey |
| Immunogen: | synthesized peptide derived from the C-terminal region of human SENP5. |
| Form: | Liquid |
| Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Synonyms: | SENP5; FKSG45; Sentrin-specific protease 5; Sentrin/SUMO-specific protease SENP5 |
| UniProt Protein Function: | SENP5: Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO3 to its mature form and deconjugation of SUMO2 and SUMO3 from targeted proteins. Has weak proteolytic activity against full-length SUMO1 or SUMO1 conjugates. Required for cell division. Belongs to the peptidase C48 family. |
| UniProt Protein Details: | Protein type:Nucleolus; Protease; EC 3.4.22.68 Chromosomal Location of Human Ortholog: 3q29 Cellular Component: intracellular membrane-bound organelle; nucleolus; nucleoplasm; nucleus Molecular Function:endopeptidase activity; protein binding; SUMO-specific protease activity Biological Process: protein desumoylation; protein sumoylation |
| NCBI Summary: | The reversible posttranslational modification of proteins by the addition of small ubiquitin-like SUMO proteins (see SUMO1; MIM 601912) is required for numerous biologic processes. SUMO-specific proteases, such as SENP5, are responsible for the initial processing of SUMO precursors to generate a C-terminal diglycine motif required for the conjugation reaction. They also have isopeptidase activity for the removal of SUMO from high molecular mass SUMO conjugates (Di Bacco et al., 2006 [PubMed 16738315]).[supplied by OMIM, Jun 2009] |
| UniProt Code: | Q96HI0 |
| NCBI GenInfo Identifier: | 296452962 |
| NCBI Gene ID: | 205564 |
| NCBI Accession: | Q96HI0.3 |
| UniProt Secondary Accession: | Q96HI0,Q96SA5, B4DY82, |
| UniProt Related Accession: | Q96HI0 |
| Molecular Weight: | 81,310 Da |
| NCBI Full Name: | Sentrin-specific protease 5 |
| NCBI Synonym Full Names: | SUMO1/sentrin specific peptidase 5 |
| NCBI Official Symbol: | SENP5Â Â |
| NCBI Protein Information: | sentrin-specific protease 5 |
| UniProt Protein Name: | Sentrin-specific protease 5 |
| UniProt Synonym Protein Names: | Sentrin/SUMO-specific protease SENP5 |
| Protein Family: | Sentrin-specific protease |
| UniProt Gene Name: | SENP5Â Â |
| UniProt Entry Name: | SENP5_HUMAN |
