The SERPINC1 Monoclonal Antibody (CAB11249) is a high-quality antibody developed for reliable detection and analysis of target proteins. This antibody, generated in rabbits, shows high specificity and sensitivity when detecting SERPINC1 in human samples, making it an ideal choice for Western blot and immunohistochemistry applications.SERPINC1 is a crucial protein in the regulation of blood coagulation, acting as a major inhibitor of thrombin and other coagulation factors. Dysregulation of SERPINC1 is linked to a range of thrombotic disorders, making it a key target for research in thrombosis and hemostasis.
This antibody is validated for use in WB, IHC-P, ELISA applications and has demonstrated reactivity against Human, Mouse, Rat samples.
Product Name:
SERPINC1 Monoclonal Antibody
SKU:
CAB11249
Size:
20μL, 100μL
Reactivity:
Human, Mouse, Rat
Clone Number:
ARC0559
Conjugate:
Unconjugated
Immunogen:
Synthetic peptide. This information is considered to be commercially sensitive.
HepG2, K-562, Rat liver, Mouse plasma, Rat plasma, Human plasma
Cellular Localization:
Secreted, Extracellular Space.
Calculated MW:
58kDa
Observed MW:
58kDa
The protein encoded by this gene, antithrombin III, is a plasma protease inhibitor and a member of the serpin superfamily. This protein inhibits thrombin as well as other activated serine proteases of the coagulation system, and it regulates the blood coagulation cascade. The protein includes two functional domains: the heparin binding-domain at the N-terminus of the mature protein, and the reactive site domain at the C-terminus. The inhibitory activity is enhanced by the presence of heparin. Numerous mutations have been identified for this gene, many of which are known to cause antithrombin-III deficiency which constitutes a strong risk factor for thrombosis. A reduction in the serum level of this protein is associated with severe cases of Coronavirus Disease 19 (COVID-19).
Purification Method
Affinity purification
Gene ID
462
RRID
AB_2861534
Buffer Information
Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol and 0.05% BSA, preserved with proclin300 or sodium azide, pH 7.3.
Western blot analysis of various lysates using SERPINC1 Rabbit mAb (CAB11249) at 1：1000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (AbGn00020). Exposure time: 90s.
Western blot analysis of various lysates using SERPINC1 Rabbit mAb (CAB11249) at 1：1000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (AbGn00020). Exposure time: 3min.
