The SETD2 Polyclonal Antibody (CAB11757) is specially designed for research involving SETD2, a crucial protein involved in chromatin remodeling and gene regulation. This antibody, produced in rabbits, shows high reactivity with human samples and has been validated for applications in Western blotting. It targets the SETD2 protein, enabling precise detection and analysis in a variety of cell types, making it perfect for studies in the fields of epigenetics and cancer research.SETD2, also known as a histone H3 lysine 36 methyltransferase, plays a vital role in maintaining genomic stability and regulating gene expression.
Mutations in SETD2 have been linked to various cancers, highlighting its importance in tumor suppression and DNA repair mechanisms. Research into SETD2 can provide valuable insights into the mechanisms underlying cancer development and progression, paving the way for potential therapeutic interventions targeting SETD2 in cancer treatment.
Product Name:
SETD2 Rabbit Polyclonal Antibody
SKU:
CAB11757
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 803-1103 of human SETD2 (NP_054878.5).
Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. This gene encodes a protein belonging to a class of huntingtin interacting proteins characterized by WW motifs. This protein is a histone methyltransferase that is specific for lysine-36 of histone H3, and methylation of this residue is associated with active chromatin. This protein also contains a novel transcriptional activation domain and has been found associated with hyperphosphorylated RNA polymerase II.
Purification Method:
Affinity purification
Gene ID:
29072
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using SETD2 Rabbit pAb (CAB11757) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 15s.
