The Shroom2 Antibody (PAC019129) is a valuable tool for researchers studying the Shroom2 protein, which is involved in cell morphology and organization. This polyclonal antibody, produced in rabbits, is highly specific for human samples and has been validated for use in various applications including Western blot analysis. By binding to the Shroom2 protein, this antibody allows for the detection and analysis of Shroom2 in different cell types, making it a versatile option for studies in cell biology and developmental biology.
Shroom2 is known for its role in regulating cell shape and movement, making it essential for processes such as cell division and tissue organization. Understanding the function of Shroom2 is crucial for unraveling its contribution to developmental disorders and diseases like cancer. By targeting the Shroom2 protein, researchers can gain insights into its involvement in cellular processes and potentially discover new therapeutic targets for various conditions.
Antibody Name:
SHROOM2 Antibody (PACO19129)
Antibody SKU:
PACO19129
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:5000, IHC:1:50-1:200
Species Reactivity:
Human
Immunogen:
Synthetic peptide of human SHROOM2
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using PACO19129(SHROOM2 Antibody) at dilution 1/50, on the right is treated with synthetic peptide. (Original magnification: x200).
The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using PACO19129(SHROOM2 Antibody) at dilution 1/50, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
The protein encoded by this gene shares significant similarities with the apical protein from Xenopus laevis which is implicated in amiloride-sensitive sodium channel activity. This gene is a strong candidate gene for ocular albinism type 1 syndrome.
Synonyms:
shroom family member 2
UniProt Protein Function:
APXL: May be involved in endothelial cell morphology changes during cell spreading. In the retinal pigment epithelium, may regulate the biogenesis of melanosomes and promote their association with the apical cell surface by inducing gamma-tubulin redistribution. Belongs to the shroom family.Protein type: Channel, sodiumChromosomal Location of Human Ortholog: Xp22.3Cellular Component: apical plasma membrane; cell-cell adherens junction; cortical actin cytoskeleton; cytoskeleton; plasma membrane; tight junctionMolecular Function: actin binding; actin filament binding; amiloride-sensitive sodium channel activity; beta-catenin binding; protein bindingBiological Process: actin filament bundle formation; apical protein localization; brain development; camera-type eye development; camera-type eye morphogenesis; cell migration; cell morphogenesis; cellular pigment accumulation; ear development; establishment of melanosome localization; eye pigment granule organization and biogenesis; lens morphogenesis in camera-type eye; melanosome organization and biogenesis
UniProt Protein Details:
NCBI Summary:
This gene represents the human homolog of Xenopus laevis apical protein (APX) gene, which is implicated in amiloride-sensitive sodium channel activity. It is expressed in endothelial cells and facilitates the formation of a contractile network within endothelial cells. Depletion of this gene results in an increase in endothelial sprouting, migration, and angiogenesis. This gene is highly expressed in the retina, and is a strong candidate for ocular albinism type 1 syndrome. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2016]
