The SLC10A3 Polyclonal Antibody (PACO50006) is a valuable tool for researchers studying the SLC10A3 protein, which is involved in sodium-dependent bile acid transport. This antibody, produced in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications. By specifically binding to the SLC10A3 protein, researchers can accurately detect and analyze its expression in various cell types, making it an excellent choice for studies in gastroenterology and hepatology.SLC10A3, a member of the solute carrier family, plays a crucial role in the absorption and transport of bile acids in the liver and intestine.
Dysregulation of bile acid transport has been linked to conditions such as cholestasis, liver diseases, and metabolic disorders. Investigating the function and regulation of SLC10A3 can provide insights into these diseases and potentially lead to the development of novel therapeutic strategies.Overall, the SLC10A3 Polyclonal Antibody is a valuable tool for researchers seeking to unravel the role of SLC10A3 in bile acid transport and its implications in various diseases, ultimately contributing to advancements in the understanding and treatment of gastrointestinal disorders.
Western Blot. Positive WB detected in: Hela whole cell lysate, Rat liver tissue. All lanes: SLC10A3 antibody at 2µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 51, 48 kDa. Observed band size: 51 kDa..
Immunohistochemistry of paraffin-embedded human liver tissue using PACO50006 at dilution of 1:100.
Immunohistochemistry of paraffin-embedded human thyroid tissue using PACO50006 at dilution of 1:100.
Background:
The ubiquitous expression and the conservation of the sequence in distant animal species suggest that the gene codes for a protein with housekeeping functions.
Synonyms:
P3 protein (Solute carrier family 10 member 3), SLC10A3, DXS253E P3
UniProt Protein Function:
SLC10A3: The ubiquitous expression and the conservation of the sequence in distant animal species suggest that the gene codes for a protein with housekeeping functions. Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Membrane protein, multi-pass; Membrane protein, integralChromosomal Location of Human Ortholog: Xq28Cellular Component: integral to plasma membraneMolecular Function: bile acid:sodium symporter activityBiological Process: bile acid and bile salt transport; response to retinoic acid; transmembrane transport
UniProt Protein Details:
NCBI Summary:
This gene maps to a GC-rich region of the X chromosome and was identified by its proximity to a CpG island. It is thought to be a housekeeping gene. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Dec 2008]
