Description
SLC18A1 Antibody (PACO47654)
The SLC18A1 Antibody (PACO47654) is a high-quality polyclonal antibody designed for research involving SLC18A1, a protein involved in neurotransmitter transport. This antibody, produced in rabbits, is highly specific and reactive with human samples, making it an excellent tool for studying the function of SLC18A1 in various biological processes.SLC18A1, also known as the vesicular monoamine transporter 1 (VMAT1), plays a crucial role in packaging and transporting neurotransmitters such as dopamine, serotonin, and norepinephrine into synaptic vesicles. Dysregulation of SLC18A1 has been implicated in various neurological disorders, including Parkinson's disease and schizophrenia, making it a promising target for therapeutic intervention.
The SLC18A1 Antibody (PACO47654) is validated for use in Western blot applications, allowing for the detection and analysis of SLC18A1 protein levels in different cell types and tissues. Researchers in the fields of neuroscience, pharmacology, and neurology will benefit from utilizing this antibody to further understand the role of SLC18A1 in neurotransmission and its potential implications in disease pathology.
| Antibody Name: | SLC18A1 Antibody (PACO47654) |
| Antibody SKU: | PACO47654 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:1000-1:5000, IHC:1:20-1:200 |
| Species Reactivity: | Human, Mouse |
| Immunogen: | Recombinant Human Chromaffin granule amine transporter protein (66-120AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western Blot. Positive WB detected in: Mouse liver tissue. All lanes: SLC18A1 antibody at 2.7µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 57, 51, 53 kDa. Observed band size: 57 kDa.. |
 | Immunohistochemistry of paraffin-embedded human placenta tissue using PACO47654 at dilution of 1:100. |
| Background: | Involved in the transport of biogenic monoamines, such as serotonin, from the cytoplasm into the secretory vesicles of neuroendocrine and endocrine cells. |
| Synonyms: | Chromaffin granule amine transporter (Solute carrier family 18 member 1) (Vesicular amine transporter 1) (VAT1), SLC18A1, VAT1 VMAT1 |
| UniProt Protein Function: | SLC18A1: Involved in the vesicular transport of biogenic amines. Belongs to the major facilitator superfamily. Vesicular transporter family. |
| UniProt Protein Details: | Protein type:Transporter, SLC family; Membrane protein, multi-pass; Membrane protein, integral; Transporter Chromosomal Location of Human Ortholog: 8p21.3 Cellular Component: endoplasmic reticulum membrane; integral to membrane Molecular Function:monoamine transmembrane transporter activity; drug transporter activity Biological Process: neurotransmitter transport; monoamine transport; multidrug transport; transmembrane transport |
| NCBI Summary: | The vesicular monoamine transporter acts to accumulate cytosolic monoamines into vesicles, using the proton gradient maintained across the vesicular membrane. Its proper function is essential to the correct activity of the monoaminergic systems that have been implicated in several human neuropsychiatric disorders. The transporter is a site of action of important drugs, including reserpine and tetrabenazine (Peter et al., 1993 [PubMed 7905859]). See also SLC18A2 (MIM 193001).[supplied by OMIM, Mar 2008] |
| UniProt Code: | P54219 |
| NCBI GenInfo Identifier: | 1722741 |
| NCBI Gene ID: | 6570 |
| NCBI Accession: | P54219.1 |
| UniProt Secondary Accession: | P54219,Q9BRE4, E9PDJ5, |
| UniProt Related Accession: | P54219 |
| Molecular Weight: | 472 |
| NCBI Full Name: | Chromaffin granule amine transporter |
| NCBI Synonym Full Names: | solute carrier family 18 (vesicular monoamine transporter), member 1 |
| NCBI Official Symbol: | SLC18A1Â Â |
| NCBI Official Synonym Symbols: | CGAT; VAT1; VMAT1Â Â |
| NCBI Protein Information: | chromaffin granule amine transporter; vesicular amine transporter 1; solute carrier family 18 member 1; solute carrier family 18 (vesicular monoamine), member 1 |
| UniProt Protein Name: | Chromaffin granule amine transporter |
| UniProt Synonym Protein Names: | Solute carrier family 18 member 1; Vesicular amine transporter 1; VAT1 |
| UniProt Gene Name: | SLC18A1Â Â |
| UniProt Entry Name: | VMAT1_HUMAN |
| Antibodies |
| SLC18A1 Antibody (PACO12245) |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
