Description
SLC22A17 Antibody (PACO01781)
The SLC22A17 Polyclonal Antibody (PACO01781) is a valuable tool for researchers studying the SLC22A17 protein, which is involved in the transport of organic cations in the kidney. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to the SLC22A17 protein, this antibody enables accurate detection and analysis in various cell types, making it well-suited for research in nephrology and pharmacology.
SLC22A17 plays a crucial role in the renal handling of organic cations, suggesting its potential importance in drug transport and metabolism. Researchers interested in understanding the mechanisms of drug excretion and renal clearance can benefit from studying the function of SLC22A17. By elucidating its role in the transport of organic cations, this antibody can contribute to the development of more effective therapies and drugs targeting renal function and drug metabolism.
| Antibody Name: | SLC22A17 Antibody |
| Antibody SKU: | PACO01781 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | WB:1:500-1:2000 |
| Species Reactivity: | Human, Mouse, Rat |
| Immunogen: | synthesized peptide derived from the Internal region of human BOCT. |
| Form: | Liquid |
| Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Synonyms: | SLC22A17; BOCT; BOIT; Solute carrier family 22 member 17; 24p3 receptor; 24p3R; Brain-type organic cation transporter; Lipocalin-2 receptor; Neutrophil gelatinase-associated lipocalin receptor; NgalR |
| UniProt Protein Function: | SLC22A17: Cell surface receptor for LCN2 (24p3) that plays a key role in iron homeostasis and transport. Able to bind iron-bound LCN2 (holo-24p3), followed by internalization of holo-24p3 and release of iron, thereby increasing intracellular iron concentration and leading to inhibition of apoptosis. Also binds iron-free LCN2 (apo-24p3), followed by internalization of apo-24p3 and its association with an intracellular siderophore, leading to iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration and resulting in apoptosis. Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, multi-pass; Transporter, SLC family; Membrane protein, integral; Transporter Chromosomal Location of Human Ortholog: 14q11.2 Cellular Component: integral to plasma membrane; vacuolar membrane Molecular Function:transmembrane receptor activity; transmembrane transporter activity Biological Process: cellular iron ion homeostasis; siderophore transport; ion transport; signal transduction; transmembrane transport |
| UniProt Code: | Q8WUG5 |
| NCBI GenInfo Identifier: | 27805426 |
| NCBI Gene ID: | 51310 |
| NCBI Accession: | Q8WUG5.1 |
| UniProt Related Accession: | Q8WUG5 |
| Molecular Weight: | |
| NCBI Full Name: | Solute carrier family 22 member 17 |
| NCBI Synonym Full Names: | solute carrier family 22 member 17 |
| NCBI Official Symbol: | SLC22A17Â Â |
| NCBI Official Synonym Symbols: | BOCT; BOIT; 24p3R; NGALR; hBOIT; NGALR2; NGALR3Â Â |
| NCBI Protein Information: | solute carrier family 22 member 17 |
| UniProt Protein Name: | Solute carrier family 22 member 17 |
| UniProt Synonym Protein Names: | 24p3 receptor; 24p3R; Brain-type organic cation transporter; Lipocalin-2 receptor; Neutrophil gelatinase-associated lipocalin receptor; NgalR |
| UniProt Gene Name: | SLC22A17Â Â |
| UniProt Entry Name: | S22AH_HUMAN |
