The SLC25A3 Antibody (PAC012269) is a polyclonal antibody designed for research involving SLC25A3, a key mitochondrial protein responsible for the transport of phosphate ions across the inner mitochondrial membrane. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By specifically binding to the SLC25A3 protein, this antibody enables accurate detection and analysis in a variety of cell types, making it an essential tool for studies in mitochondrial biology, metabolism, and energy production.
SLC25A3 is a crucial mitochondrial transporter that plays a vital role in cellular energy metabolism by facilitating the exchange of metabolites between the mitochondria and cytosol. Dysregulation of SLC25A3 has been implicated in various metabolic disorders, neurodegenerative diseases, and mitochondrial dysfunction syndromes. Investigating the function and regulation of SLC25A3 is essential for understanding its role in cellular homeostasis and developing targeted therapies for related disorders.
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3;SLC25A3;OK/SW-cl.48;PHC ;
UniProt Protein Function:
SLC25A3: Transport of phosphate groups from the cytosol to the mitochondrial matrix. Phosphate is cotransported with H(+). Defects in SLC25A3 are a cause of mitochondrial phosphate carrier deficiency (MPCD). MPCD is a fatal disorder of oxidative phosphorylation. Patients have lactic acidosis, hypertrophic cardiomyopathy and muscular hypotonia and die within the first year of life. Belongs to the mitochondrial carrier family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Membrane protein, integral; Transporter, SLC family; Membrane protein, multi-pass; Mitochondrial; TransporterChromosomal Location of Human Ortholog: 12q23Cellular Component: membrane; mitochondrion; integral to plasma membrane; mitochondrial inner membraneMolecular Function: phosphate carrier activity; symporter activity; protein complex bindingBiological Process: generation of precursor metabolites and energy; transportDisease: Mitochondrial Phosphate Carrier Deficiency
UniProt Protein Details:
NCBI Summary:
The protein encoded by this gene catalyzes the transport of phosphate into the mitochondrial matrix, either by proton cotransport or in exchange for hydroxyl ions. The protein contains three related segments arranged in tandem which are related to those found in other characterized members of the mitochondrial carrier family. Both the N-terminal and C-terminal regions of this protein protrude toward the cytosol. Multiple alternatively spliced transcript variants have been isolated. [provided by RefSeq, Jul 2008]
