The SLC46A1 Polyclonal Antibody (CAB7397) is a high-quality antibody developed for reliable detection and analysis of target proteins. This antibody, also raised in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications.SLC46A1, also known as the proton-coupled folate transporter (PCFT), is essential for the uptake of folate, a crucial vitamin for DNA synthesis and cell growth. Dysregulation of folate transport has been implicated in various diseases, including cancer and neurological disorders. The SLC46A1 Polyclonal Antibody enables the detection and analysis of SLC46A1 protein levels in different cell types, making it a valuable tool for research in the fields of biochemistry, molecular biology, and pharmacology.
This antibody is validated for use in WB, ELISA applications and has demonstrated reactivity against Human, Mouse, Rat samples.
Product Name:
SLC46A1 Polyclonal Antibody
SKU:
CAB7397
Size:
20μL, 100μL
Reactivity:
Human, Mouse, Rat
Conjugate:
Unconjugated
Immunogen:
Recombinant protein (or fragment).This information is considered to be commercially sensitive.
This gene encodes a transmembrane proton-coupled folate transporter protein that facilitates the movement of folate and antifolate substrates across cell membranes, optimally in acidic pH environments. This protein is also expressed in the brain and choroid plexus where it transports folates into the central nervous system. This protein further functions as a heme transporter in duodenal enterocytes, and potentially in other tissues like liver and kidney. Its localization to the apical membrane or cytoplasm of intestinal cells is modulated by dietary iron levels. Mutations in this gene are associated with autosomal recessive hereditary folate malabsorption disease. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
Purification Method
Affinity purification
Gene ID
113235
RRID
AB_2767929
Buffer Information
Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol, preserved with proclin300 or sodium azide, pH 7.3.
Western blot analysis of various lysates, using SLC46A1 Rabbit pAb (CAB7397) at 1:2000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (AbGn00021). Exposure time: 30s.
