SMC6 Antibody (PACO20556)
- SKU:
- PACO20556
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
SMC6 Antibody (PACO20556)
The SMC6 Polyclonal Antibody (PAC020556) is specifically designed for research involving the SMC6 protein, a critical component of the SMC5/6 complex involved in DNA repair and genome stability. This antibody, produced in rabbits, is highly reactive with human samples and is validated for use in applications such as Western blot and immunofluorescence.SMC6 is essential for maintaining genomic integrity by facilitating DNA repair processes and ensuring proper chromosome segregation during cell division. Dysregulation of SMC6 has been implicated in a variety of human diseases, including cancer and developmental disorders.
Therefore, studying the function of SMC6 is crucial for advancing our understanding of these conditions and developing targeted therapies.By using the SMC6 Polyclonal Antibody, researchers can effectively detect and analyze the expression of SMC6 in various cell types, providing valuable insights into its role in genome maintenance and disease development. This antibody is a valuable tool for studies in molecular biology, genetics, and cancer research, offering a deeper understanding of the mechanisms underlying DNA repair and genome stability.
| Antibody Name: | SMC6 Antibody (PACO20556) |
| Antibody SKU: | PACO20556 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:5000, WB:1:500-1:2000, IHC:1:20-1:100 |
| Species Reactivity: | Human |
| Immunogen: | Synthetic peptide of human SMC6 |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO20556(SMC6 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200). |
 | Gel: 6%SDS-PAGE, Lysate: 40 µg, Lane 1-4: Jurkat cells, 231 cells, hela cells, 293T cells, Primary antibody: PACO20556(SMC6 Antibody) at dilution 1/250, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 2 minutes. |
 | The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using PACO20556(SMC6 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200). |
| Background: | Structural maintenance of chromosomes protein 6 is a protein that in humans is encoded by the SMC6 gene. Core component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. |
| Synonyms: | structural maintenance of chromosomes 6 |
| UniProt Protein Function: | SMC6L1: Core component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). Required for recruitment of telomeres to PML nuclear bodies. Belongs to the SMC family. SMC6 subfamily. 2 isoforms of the human protein are produced by alternative splicing.Protein type: DNA repair, damageChromosomal Location of Human Ortholog: 2p24.2Cellular Component: nucleoplasm; chromosome, telomeric region; PML body; nucleolus; intracellular; nucleusMolecular Function: protein binding; ATP bindingBiological Process: telomere maintenance via recombination; double-strand break repair via homologous recombination |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | Q96SB8 |
| NCBI GenInfo Identifier: | 122070455 |
| NCBI Gene ID: | 79677 |
| NCBI Accession: | Q96SB8.2 |
| UniProt Secondary Accession: | Q96SB8 |
| UniProt Related Accession: | Q96SB8 |
| Molecular Weight: | 126kDa |
| NCBI Full Name: | Structural maintenance of chromosomes protein 6 |
| NCBI Synonym Full Names: | structural maintenance of chromosomes 6 |
| NCBI Official Symbol: | SMC6 |
| NCBI Official Synonym Symbols: | SMC-6; hSMC6; SMC6L1 |
| NCBI Protein Information: | structural maintenance of chromosomes protein 6 |
| UniProt Protein Name: | Structural maintenance of chromosomes protein 6 |
| UniProt Synonym Protein Names: | |
| Protein Family: | Structural maintenance of chromosomes protein |
| UniProt Gene Name: | SMC6 |
| UniProt Entry Name: | SMC6_HUMAN |
| Antibodies |
| SMC6 Antibody (PACO12341) |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
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