Description
SNX20 Antibody (PACO30048)
The SNX20 Polyclonal Antibody (PACO30048) is a valuable tool for researchers studying SNX20, a key protein involved in endosomal protein sorting and membrane trafficking. This antibody, generated in rabbits, exhibits high reactivity with human samples and is suitable for use in Western blot applications. By specifically binding to SNX20, researchers can accurately detect and analyze the protein in a variety of cell types, making it ideal for investigations in cell biology and molecular biology.SNX20, a member of the sorting nexin family, plays a crucial role in regulating the transport of proteins within cells, impacting various cellular processes such as receptor recycling and degradation.
Dysregulation of SNX20 function has been linked to diseases including cancer, neurodegenerative disorders, and metabolic diseases, highlighting its importance as a potential therapeutic target. By studying SNX20 with the use of this antibody, researchers can gain insights into its role in these disease processes and develop targeted interventions to modulate its activity.
| Antibody Name: | SNX20 Antibody (PACO30048) |
| Antibody SKU: | PACO30048 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:1000-1:5000, IHC:1:10-1:200 |
| Species Reactivity: | Human, Mouse |
| Immunogen: | Recombinant Human Sorting nexin-20 protein (1-102AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western blot All lanes: SNX20 antibody at 2µg/ml Lane 1: Mouse spleen tissue Lane 2: Mouse skeletal muscle tissue Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 37, 18, 15, 12 kDa Observed band size: 37 kDa . |
 | Immunohistochemistry of paraffin-embedded human placenta tissue using PACO30048 at dilution of 1:10. |
| Background: | Serves as a sorting protein that cycles P-selectin glycoprotein ligand 1 (PSLG1) into endosomes with no impact on leukocytes recruitment. |
| Synonyms: | Sorting nexin-20 (Selectin ligand-interactor cytoplasmic 1) (SLIC-1), SNX20, SLIC1 |
| UniProt Protein Function: | SNX20: Serves as a sorting protein that cycles P-selectin glycoprotein ligand 1 (PSLG1) into endosomes with no impact on leukocytes recruitment. Belongs to the sorting nexin family. 4 isoforms of the human protein are produced by alternative splicing.Protein type: Lipid-bindingChromosomal Location of Human Ortholog: 16q12.1Cellular Component: plasma membrane; endosome membrane; nucleusMolecular Function: protein binding; phosphoinositide bindingBiological Process: protein transport |
| UniProt Protein Details: | |
| NCBI Summary: | SNX20 interacts with the cytoplasmic domain of PSGL1 (SELPLG; MIM 600738) and cycles PSGL1 into endosomes.[supplied by OMIM, Feb 2010] |
| UniProt Code: | Q7Z614 |
| NCBI GenInfo Identifier: | 115527721 |
| NCBI Gene ID: | 124460 |
| NCBI Accession: | AAI19627.1 |
| UniProt Secondary Accession: | Q7Z614,Q08E98, Q6P4H2, Q8IV59, A8K9D5 |
| UniProt Related Accession: | Q7Z614 |
| Molecular Weight: | 36,178 Da |
| NCBI Full Name: | SNX20 protein |
| NCBI Synonym Full Names: | sorting nexin 20 |
| NCBI Official Symbol: | SNX20Â Â |
| NCBI Official Synonym Symbols: | SLIC1Â Â |
| NCBI Protein Information: | sorting nexin-20; selectin ligand interactor cytoplasmic 1; selectin ligand interactor cytoplasmic-1; selectin ligand-interactor cytoplasmic 1 |
| UniProt Protein Name: | Sorting nexin-20 |
| UniProt Synonym Protein Names: | Selectin ligand-interactor cytoplasmic 1 |
| Protein Family: | Sorting nexin |
| UniProt Gene Name: | SNX20Â Â |
| UniProt Entry Name: | SNX20_HUMAN |
| Antibodies |
| SNX20 Antibody (PACO12380) |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
