The SNX27 Polyclonal Antibody (PAC017131) is a valuable tool for researchers studying SNX27, a crucial protein involved in intracellular trafficking and membrane protein recycling. This antibody, generated in rabbits, exhibits high specificity for human samples and has been validated for use in Western blot applications.SNX27 plays a significant role in the regulation of receptor sorting and recycling, making it a key player in various cellular processes such as signal transduction and receptor endocytosis. Its importance in maintaining cellular homeostasis and proper functioning makes it a promising target for studies in cell biology and neurodegenerative diseases.
By using the SNX27 Polyclonal Antibody, researchers can accurately detect and analyze SNX27 protein levels in different cell types, providing valuable insights into its functions and potential implications in various pathological conditions. This antibody is a valuable tool for investigating the mechanisms underlying intracellular protein trafficking and could lead to the development of novel therapeutic strategies targeting SNX27-related pathways.
Antibody Name:
SNX27 Antibody (PACO17131)
Antibody SKU:
PACO17131
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:5000, IHC:1:25-1:100
Species Reactivity:
Human, Mouse, Rat
Immunogen:
Fusion protein of human SNX27
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using PACO17131(SNX27 Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: x200).
Background:
This gene encodes a member of the sorting nexin family, a diverse group of cytoplasmic and membrane-associated proteins involved in endocytosis of plasma membrane receptors and protein trafficking through these compartments. All members of this protein family contain a phosphoinositide binding domain (PX domain). A highly similar protein in mouse is responsible for the specific recruitment of an isoform of serotonin 5-hydroxytryptamine 4 receptor into early endosomes, suggesting the analogous role for the human protein.
Synonyms:
sorting nexin family member 27
UniProt Protein Function:
SNX27: Involved in endocytic trafficking. In T lymphocytes, participates in endocytic recycling pathway. Recruits PSCDBP and HT4R to early endosomes. Belongs to the sorting nexin family. 4 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:
Protein type:Vesicle
Chromosomal Location of Human Ortholog: 1q21.3
Cellular Component: cytoplasm; early endosome; immunological synapse; nucleoplasm; retromer complex
Molecular Function:phosphatidylinositol 3-phosphate binding; protein binding
Biological Process: endosome transport; establishment of natural killer cell polarity; intracellular protein transport
NCBI Summary:
This gene encodes a member of the sorting nexin family, a diverse group of cytoplasmic and membrane-associated proteins involved in endocytosis of plasma membrane receptors and protein trafficking through these compartments. All members of this protein family contain a phosphoinositide binding domain (PX domain). A highly similar protein in mouse is responsible for the specific recruitment of an isoform of serotonin 5-hydroxytryptamine 4 receptor into early endosomes, suggesting the analogous role for the human protein. [provided by RefSeq, Jul 2008]
