The Sox8 Polyclonal Antibody (PACO18909) is a valuable tool for research involving the Sox8 protein, a transcription factor that plays a crucial role in embryonic development and cell differentiation. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in a variety of applications, including Western blot and immunohistochemistry.Sox8 is known to regulate the expression of genes involved in cell fate determination, making it a key player in developmental processes such as neurogenesis and chondrogenesis. Dysregulation of Sox8 has been linked to various diseases, including neurodevelopmental disorders and certain types of cancer.
By targeting Sox8 with this antibody, researchers can gain valuable insights into the molecular mechanisms underlying these conditions and potentially identify new therapeutic targets.With its ability to specifically bind to Sox8, the PACO18909 antibody enables precise detection and analysis of this important transcription factor in different cell types and tissues. Its versatility and reliability make it a valuable tool for studies in developmental biology, cancer research, and beyond. By elucidating the functions of Sox8, researchers can advance our understanding of complex biological processes and potentially uncover novel strategies for treating a range of diseases.
Antibody Name:
SOX8 Antibody (PACO18909)
Antibody SKU:
PACO18909
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:2000-1:5000, WB:1:500-1:2000
Species Reactivity:
Human, Mouse
Immunogen:
Synthetic peptide of human SOX8
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane: Human fetal brain tissue, Primary antibody: PACO18909(SOX8 Antibody) at dilution 1/500, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 2 minutes.
Background:
This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional activator after forming a protein complex with other proteins. This protein may be involved in brain development and function. Haploinsufficiency for this protein may contribute to the mental retardation found in haemoglobin H-related mental retardation (ART-16 syndrome).
Synonyms:
SRY (sex determining region Y)-box 8
UniProt Protein Function:
SOX8: May play a role in central nervous system, limb and facial development. May be involved in male sex determination. Binds the consensus motif 5'-[AT][AT]CAA[AT]G-3'.
UniProt Protein Details:
Protein type:DNA-binding
Chromosomal Location of Human Ortholog: 16p13.3
Cellular Component: cytoplasm; nucleus
Molecular Function:DNA binding; protein heterodimerization activity; transcription factor binding
Biological Process: negative regulation of photoreceptor cell differentiation; transcription from RNA polymerase II promoter; fat cell differentiation; cell fate commitment; positive regulation of gliogenesis; in utero embryonic development; astrocyte fate commitment; positive regulation of transcription, DNA-dependent; male gonad development; cell maturation; signal transduction; Sertoli cell development; enteric nervous system development; peripheral nervous system development; osteoblast differentiation; retina development in camera-type eye; positive regulation of osteoblast proliferation; oligodendrocyte differentiation; spermatogenesis; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; negative regulation of myoblast differentiation; neural crest cell migration; negative regulation of apoptosis
NCBI Summary:
This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional activator after forming a protein complex with other proteins. This protein may be involved in brain development and function. Haploinsufficiency for this protein may contribute to the mental retardation found in haemoglobin H-related mental retardation (ART-16 syndrome). [provided by RefSeq, Jul 2008]
