SOX8/SOX9/SOX17/SOX18 Antibody (PACO01526)
- SKU:
- PACO01526
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- NHP - Monkey
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | SOX8/SOX9/SOX17/SOX18 Antibody |
| Antibody SKU: | PACO01526 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC |
| Recommended Dilutions: | WB:1:500-1:2000, IHC:1:100-1:300 |
| Species Reactivity: | Human, Mouse, Monkey |
| Immunogen: | synthesized peptide derived from the Internal region of human Sox-8/9/17/18. |
| Form: | Liquid |
| Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Synonyms: | SOX8; Transcription factor SOX-8; SOX9; Transcription factor SOX-9; SOX17; Transcription factor SOX-17; SOX18; Transcription factor SOX-18 |
| UniProt Protein Function: | SOX8: May play a role in central nervous system, limb and facial development. May be involved in male sex determination. Binds the consensus motif 5'-[AT][AT]CAA[AT]G-3'. |
| UniProt Protein Details: | Protein type:DNA-binding Chromosomal Location of Human Ortholog: 16p13.3 Cellular Component: cytoplasm; nucleus Molecular Function:DNA binding; protein heterodimerization activity; transcription factor binding Biological Process: negative regulation of photoreceptor cell differentiation; transcription from RNA polymerase II promoter; fat cell differentiation; cell fate commitment; positive regulation of gliogenesis; in utero embryonic development; astrocyte fate commitment; positive regulation of transcription, DNA-dependent; male gonad development; cell maturation; signal transduction; Sertoli cell development; enteric nervous system development; peripheral nervous system development; osteoblast differentiation; retina development in camera-type eye; positive regulation of osteoblast proliferation; oligodendrocyte differentiation; spermatogenesis; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; negative regulation of myoblast differentiation; neural crest cell migration; negative regulation of apoptosis |
| NCBI Summary: | This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional activator after forming a protein complex with other proteins. This protein may be involved in brain development and function. Haploinsufficiency for this protein may contribute to the mental retardation found in haemoglobin H-related mental retardation (ART-16 syndrome). [provided by RefSeq, Jul 2008] |
| UniProt Code: | P57073 |
| NCBI GenInfo Identifier: | 10720294 |
| NCBI Gene ID: | 30812 |
| NCBI Accession: | P57073.1 |
| UniProt Secondary Accession: | P57073,P48436, Q9H6I2, P35713, |
| UniProt Related Accession: | P57073 |
| Molecular Weight: | 446 |
| NCBI Full Name: | Transcription factor SOX-8 |
| NCBI Synonym Full Names: | SRY (sex determining region Y)-box 8 |
| NCBI Official Symbol: | SOX8Â Â |
| NCBI Protein Information: | transcription factor SOX-8 |
| UniProt Protein Name: | Transcription factor SOX-8 |
| Protein Family: | Transcription factor |
| UniProt Gene Name: | SOX8Â Â |
| UniProt Entry Name: | SOX8_HUMAN |
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