Description
SOX8/SOX9/SOX17/SOX18 Antibody (PACO01526)
The SOX8/SOX9/SOX17/SOX18 Antibody (PACO01526) is a powerful tool for researchers studying the SOX family of transcription factors, which play essential roles in development and cell differentiation. This polyclonal antibody, generated in rabbits, is specifically designed for recognizing these SOX proteins in human samples and has been validated for use in Western blot applications.SOX transcription factors are known for their involvement in various cellular processes, including embryonic development, stem cell maintenance, and tissue-specific gene expression. The SOX8/SOX9/SOX17/SOX18 Antibody allows for the detection and analysis of these important proteins in a wide range of cell types, making it an invaluable resource for studies in developmental biology, regenerative medicine, and cancer research.
Researchers can use this antibody to explore the functions and regulatory mechanisms of SOX8, SOX9, SOX17, and SOX18 in normal development and disease, providing insights into potential therapeutic targets for conditions such as congenital disorders, infertility, and cancer. By understanding the molecular pathways involving these SOX proteins, scientists can uncover new avenues for treatment and intervention in various health conditions.
| Antibody Name: | SOX8/SOX9/SOX17/SOX18 Antibody |
| Antibody SKU: | PACO01526 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC |
| Recommended Dilutions: | WB:1:500-1:2000, IHC:1:100-1:300 |
| Species Reactivity: | Human, Mouse, Monkey |
| Immunogen: | synthesized peptide derived from the Internal region of human Sox-8/9/17/18. |
| Form: | Liquid |
| Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Synonyms: | SOX8; Transcription factor SOX-8; SOX9; Transcription factor SOX-9; SOX17; Transcription factor SOX-17; SOX18; Transcription factor SOX-18 |
| UniProt Protein Function: | SOX8: May play a role in central nervous system, limb and facial development. May be involved in male sex determination. Binds the consensus motif 5'-[AT][AT]CAA[AT]G-3'. |
| UniProt Protein Details: | Protein type:DNA-binding Chromosomal Location of Human Ortholog: 16p13.3 Cellular Component: cytoplasm; nucleus Molecular Function:DNA binding; protein heterodimerization activity; transcription factor binding Biological Process: negative regulation of photoreceptor cell differentiation; transcription from RNA polymerase II promoter; fat cell differentiation; cell fate commitment; positive regulation of gliogenesis; in utero embryonic development; astrocyte fate commitment; positive regulation of transcription, DNA-dependent; male gonad development; cell maturation; signal transduction; Sertoli cell development; enteric nervous system development; peripheral nervous system development; osteoblast differentiation; retina development in camera-type eye; positive regulation of osteoblast proliferation; oligodendrocyte differentiation; spermatogenesis; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; negative regulation of myoblast differentiation; neural crest cell migration; negative regulation of apoptosis |
| NCBI Summary: | This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional activator after forming a protein complex with other proteins. This protein may be involved in brain development and function. Haploinsufficiency for this protein may contribute to the mental retardation found in haemoglobin H-related mental retardation (ART-16 syndrome). [provided by RefSeq, Jul 2008] |
| UniProt Code: | P57073 |
| NCBI GenInfo Identifier: | 10720294 |
| NCBI Gene ID: | 30812 |
| NCBI Accession: | P57073.1 |
| UniProt Secondary Accession: | P57073,P48436, Q9H6I2, P35713, |
| UniProt Related Accession: | P57073 |
| Molecular Weight: | 446 |
| NCBI Full Name: | Transcription factor SOX-8 |
| NCBI Synonym Full Names: | SRY (sex determining region Y)-box 8 |
| NCBI Official Symbol: | SOX8Â Â |
| NCBI Protein Information: | transcription factor SOX-8 |
| UniProt Protein Name: | Transcription factor SOX-8 |
| Protein Family: | Transcription factor |
| UniProt Gene Name: | SOX8Â Â |
| UniProt Entry Name: | SOX8_HUMAN |
