The SPATA17 Polyclonal Antibody (PAC015063) is a valuable tool for researchers studying SPATA17, a protein involved in spermatogenesis and male fertility. This antibody, raised in rabbits, exhibits high specificity and sensitivity towards human samples, making it ideal for use in a variety of applications, including Western blotting and immunohistochemistry.SPATA17, also known as Spermatogenesis-associated protein 17, plays a crucial role in the development and function of male germ cells. Mutations in SPATA17 have been associated with male infertility and impaired spermatogenesis, making it a key target for research in reproductive biology and fertility treatments.
By detecting and analyzing SPATA17 protein expression, researchers can gain valuable insights into its function and potential therapeutic applications in male reproductive health.Overall, the SPATA17 Polyclonal Antibody is a reliable tool for investigating the role of SPATA17 in male fertility and spermatogenesis, paving the way for advancements in reproductive medicine and infertility treatments.
The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using PACO15063(SPATA17 Antibody) at dilution 1/15, on the right is treated with fusion protein. (Original magnification: x200).
Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane: Human liver cancer tissue, Primary antibody: PACO15063(SPATA17 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 minutes.
The image on the left is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using PACO15063(SPATA17 Antibody) at dilution 1/15, on the right is treated with fusion protein. (Original magnification: x200).
Background:
Spata17 gene, which called MSRG11, by digital differential display of ESTs found only in testis. The deduced 292-amino acid, protein was considered to be a member of the family of calmodulin (CaM)-binding proteins because it contained 3 short CaM-binding motifs containing conserved ile and gln residues (IQ motif). Spata17 protein was most abundant in the cytoplasm of round spermatids and elongating spermatids within seminiferous tubules of the adult testis. Expression gradually decreased in the manipulated testis of animals that underwent experimental unilateral cryptorchidism. Transient transfection experiments with a Spata17 expression construct in cultured spermatogonia GC-1 cells indicated that Spata17 accelerated apoptosis in a dose-dependent manner.
Synonyms:
spermatogenesis associated 17
UniProt Protein Function:
SPATA17: Chromosomal Location of Human Ortholog: 1q41Cellular Component: cytoplasmMolecular Function: calmodulin binding
