The SPNS2 Polyclonal Antibody (PAC046794) is a valuable tool for researchers studying SPNS2, a key player in lipid metabolism and immune cell function. This antibody, generated in rabbits, exhibits strong reactivity with human samples and is specifically validated for use in immunohistochemistry applications. By targeting the SPNS2 protein, this antibody allows for precise detection and analysis in various biological samples, making it an essential tool for studies in lipid biology and immunology.SPNS2 is a crucial transporter protein that facilitates the movement of sphingosine-1-phosphate (S1P), a lipid signaling molecule, across cell membranes.
This process is vital for regulating immune cell trafficking and immune response modulation. With its involvement in lipid metabolism and immune cell function, SPNS2 is a promising target for research focused on inflammatory disorders, autoimmune diseases, and cancer. Understanding the role of SPNS2 in these conditions could lead to the development of innovative therapies targeting lipid metabolism and immune cell regulation.
Antibody Name:
SPNS2 Antibody (PACO46794)
Antibody SKU:
PACO46794
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IF
Recommended Dilutions:
ELISA:1:2000-1:10000, IF:1:50-1:200
Species Reactivity:
Human
Immunogen:
Recombinant Human Protein spinster homolog 2 protein (1-140AA)
Immunofluorescent analysis of HepG2 cells using PACO46794 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Background:
Sphingolipid transporter required for migration of myocardial precursors. Transports sphingosine 1-phosphate (S1P), a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. Mediates the export of S1P from cells in the extraembryonic yolk syncytial layer (YSL), thereby regulating myocardial precursor migration.
Synonyms:
Protein spinster homolog 2, SPNS2
UniProt Protein Function:
SPNS2: Sphingolipid transporter required for migration of myocardial precursors. Transports sphingosine 1-phosphate (S1P), a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. Mediates the export of S1P from cells in the extraembryonic yolk syncytial layer (YSL), thereby regulating myocardial precursor migration. Belongs to the major facilitator (TC 2.A.1) superfamily. Spinster (TC 2.A.1.49) family.Protein type: Membrane protein, multi-pass; Membrane protein, integralChromosomal Location of Human Ortholog: 17p13.2Cellular Component: lysosomal membrane; vesicleMolecular Function: sphingolipid transporter activityBiological Process: locomotion
UniProt Protein Details:
NCBI Summary:
The protein encoded by this gene is a transporter of sphingosine 1-phosphate, a secreted lipid that is important in cardiovascular, immunological, and neural development. Defects in this gene are a cause of early onset progressive hearing loss. [provided by RefSeq, Jul 2016]
