The STXBP1 Polyclonal Antibody (CAB5420) is a valuable tool for researchers studying STXBP1, a crucial protein involved in neurotransmitter release and synaptic vesicle fusion. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for Western blot applications. By binding specifically to STXBP1, researchers can confidently detect and analyze this protein in a variety of cell types, making it an essential asset for neuroscience and neurobiology research.STXBP1, also known as MUNC18-1, is essential for proper synaptic transmission and neurotransmitter release in the brain.
Dysregulation of STXBP1 has been linked to a range of neurological disorders, including epilepsy and intellectual disabilities, highlighting its importance in neuronal function. Research into STXBP1 can provide valuable insights into the underlying mechanisms of these conditions and potentially lead to the development of novel therapeutic interventions targeting synaptic dysfunction. Discovering the role of STXBP1 in neurological disorders is crucial for advancing our understanding of brain function and developing effective treatments for these conditions.
Product Name:
STXBP1 Rabbit Polyclonal Antibody
SKU:
CAB5420
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 295-594 of human STXBP1 (NP_001027392.1).
This gene encodes a syntaxin-binding protein. The encoded protein appears to play a role in release of neurotransmitters via regulation of syntaxin, a transmembrane attachment protein receptor. Mutations in this gene have been associated with infantile epileptic encephalopathy-4. Alternatively spliced transcript variants have been described.
Purification Method:
Affinity purification
Gene ID:
6812
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Immunofluorescence analysis of rat brain using STXBP1 antibody (CAB5420) at dilution of 1:50. Blue: DAPI for nuclear staining.
