Description
SULT1B1 Antibody (PACO30218)
The SULT1B1 Polyclonal Antibody (PACO30218) is a valuable tool for researchers studying SULT1B1, an enzyme involved in the sulfonation of various endogenous compounds and xenobiotics. This antibody, produced in rabbits, has high reactivity with human samples and is validated for use in Western blot applications. By binding specifically to the SULT1B1 protein, researchers can accurately detect and analyze its expression in different cell types, making it an essential reagent for studies in drug metabolism, toxicology, and cancer research.
SULT1B1 plays a crucial role in the metabolism of drugs and other foreign compounds in the body, making it a key player in drug interactions and individual responses to medications. Understanding the function of SULT1B1 is important for developing personalized medicine approaches and improving drug safety and efficacy. Research on SULT1B1 can also provide insights into its role in cancer development and progression, opening avenues for targeted therapies and biomarker discovery.
| Antibody Name: | SULT1B1 Antibody (PACO30218) |
| Antibody SKU: | PACO30218 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:1000, IHC:1:20-1:200 |
| Species Reactivity: | Human, Mouse |
| Immunogen: | Recombinant Human Sulfotransferase family cytosolic 1B member 1 protein (1-271AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western blot All lanes: SULT1B1 antibody at 24µg/ml + Mouse small intestine tissue Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 35 kDa Observed band size: 35 kDa . |
 | Immunohistochemistry of paraffin-embedded human small intestine tissue using PACO30218 at dilution of 1:100. |
| Background: | Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs and xenobiotic compounds. Sulfonation increases the water solubility of most compounds, and therefore their renal excretion, but it can also result in bioactivation to form active metabolites. Sulfates dopamine, small phenols such as 1-naphthol and p-nitrophenol and thyroid hormones, including 3,3'-diiodothyronine, triidothyronine, reverse triiodothyronine and thyroxine. |
| Synonyms: | Sulfotransferase family cytosolic 1B member 1 (ST1B1) (Sulfotransferase 1B1) (EC 2.8.2.-) (Sulfotransferase 1B2) (ST1B2) (Thyroid hormone sulfotransferase), SULT1B1, ST1B2 SULT1B2 |
| UniProt Protein Function: | SULT1B1: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs and xenobiotic compounds. Sulfonation increases the water solubility of most compounds, and therefore their renal excretion, but it can also result in bioactivation to form active metabolites. Sulfates dopamine, small phenols such as 1-naphthol and p-nitrophenol and thyroid hormones, including 3,3'-diiodothyronine, triidothyronine, reverse triiodothyronine and thyroxine. Belongs to the sulfotransferase 1 family. |
| UniProt Protein Details: | Protein type:EC 2.8.2.-; Transferase Chromosomal Location of Human Ortholog: 4q13.3 Cellular Component: cytosol Molecular Function:sulfotransferase activity; aryl sulfotransferase activity Biological Process: steroid metabolic process; biogenic amine metabolic process; epithelial cell differentiation; flavonoid metabolic process; xenobiotic metabolic process; sulfation; 3'-phosphoadenosine 5'-phosphosulfate metabolic process; thyroid hormone metabolic process; phenol metabolic process |
| NCBI Summary: | Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. However, the total genomic length of this gene is greater than that of other SULT1 genes. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O43704 |
| NCBI GenInfo Identifier: | 57013032 |
| NCBI Gene ID: | 27284 |
| NCBI Accession: | O43704.2 |
| UniProt Secondary Accession: | O43704,O15497, Q96FI1, Q9UK34, |
| UniProt Related Accession: | O43704 |
| Molecular Weight: | 296 |
| NCBI Full Name: | Sulfotransferase family cytosolic 1B member 1 |
| NCBI Synonym Full Names: | sulfotransferase family, cytosolic, 1B, member 1 |
| NCBI Official Symbol: | SULT1B1Â Â |
| NCBI Official Synonym Symbols: | ST1B1; ST1B2; SULT1B2Â Â |
| NCBI Protein Information: | sulfotransferase family cytosolic 1B member 1; sulfotransferase 1B1; sulfotransferase 1B2; thyroid hormone sulfotransferase |
| UniProt Protein Name: | Sulfotransferase family cytosolic 1B member 1 |
| UniProt Synonym Protein Names: | Sulfotransferase 1B2; ST1B2; Thyroid hormone sulfotransferase |
| Protein Family: | Sulfotransferase family cytosolic |
| UniProt Gene Name: | SULT1B1Â Â |
| UniProt Entry Name: | ST1B1_HUMAN |
| Antibodies |
| SULT1B1 Antibody (PACO12578) |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
