The TAGAP Polyclonal Antibody (PAC037910) is an essential tool for researchers studying TAGAP, a protein known for its role in immune regulation and immune-related diseases. This antibody, produced in rabbits, exhibits high specificity and sensitivity when detecting TAGAP in human samples, making it a reliable tool for Western blot applications. TAGAP, or T-cell activation RhoGTPase activating protein, is involved in immune cell activation and has been implicated in autoimmune disorders, such as multiple sclerosis and rheumatoid arthritis.
By targeting TAGAP, researchers can gain valuable insights into the molecular mechanisms underlying these conditions and potentially identify new therapeutic targets for treatment. This antibody enables the precise detection and analysis of TAGAP in various cell types, allowing for detailed studies in immunology and disease research. By understanding the functions and regulation of TAGAP, researchers can advance our knowledge of immune response modulation and potentially develop innovative therapies for immune-related diseases.
Antibody Name:
TAGAP Antibody (PACO37910)
Antibody SKU:
PACO37910
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:10000, IHC:1:20-1:200
Species Reactivity:
Human
Immunogen:
Recombinant Human T-cell activation Rho GTPase-activating protein (97-260AA)
TAGAP: an apparent GTPase-activating protein (GAP) for Rho monomeric G proteins. May play important roles during T-cell activation. Mutations have been associated with various autoimmune conditions including rheumatoid arthritis, Crohn¿s disease, and celiac disease. Four isoforms of the human protein are produced by alternative splicing.Protein type: GAPs, Rac/Rho; GAPsChromosomal Location of Human Ortholog: 6q25.3Cellular Component: cytosolMolecular Function: GTPase activator activityBiological Process: regulation of small GTPase mediated signal transduction
UniProt Protein Details:
NCBI Summary:
This gene encodes a member of the Rho GTPase-activator protein superfamily. The encoded protein may function as a Rho GTPase-activating protein. Alterations in this gene may be associated with several diseases, including rheumatoid arthritis, celiac disease, and multiple sclerosis. Alternate splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2013]
