Description
TEF Antibody (PACO01603)
The TEF Polyclonal Antibody (PACO01603) is a crucial tool for researchers studying transcription enhancer factor (TEF), a transcription factor involved in regulating gene expression. This antibody, produced in rabbits, exhibits high specificity and sensitivity when used in Western blot applications, enabling accurate detection of TEF protein levels in various cell types.TEF is known to play a key role in controlling cell growth, differentiation, and response to environmental stimuli, making it a significant target in cancer research and developmental biology studies. Understanding the function and regulation of TEF is essential for unraveling the molecular mechanisms underlying these processes and identifying potential therapeutic targets.
With its proven reliability and versatility in detecting TEF protein, the PACO01603 antibody is a valuable asset for researchers looking to deepen their understanding of gene expression regulation and its implications in various biological processes. It provides a powerful tool for investigating the role of TEF in both normal physiological functions and disease states, paving the way for new insights and discoveries in the field of molecular biology.
| Antibody Name: | TEF Antibody |
| Antibody SKU: | PACO01603 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC |
| Recommended Dilutions: | WB:1:500-1:2000, IHC:1:100-1:300 |
| Species Reactivity: | Human, Mouse, Rat |
| Immunogen: | synthesized peptide derived from the C-terminal region of human TEF. |
| Form: | Liquid |
| Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Synonyms: | TEF; KIAA1655; Thyrotroph embryonic factor |
| UniProt Protein Function: | TEF: Transcription factor that binds to and transactivates the TSHB promoter. Binds to a minimal DNA-binding sequence 5'- [TC][AG][AG]TTA[TC][AG]-3'. Belongs to the bZIP family. PAR subfamily. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Transcription factor; DNA-binding Chromosomal Location of Human Ortholog: 22q13.2 Cellular Component: nucleus Molecular Function:double-stranded DNA binding; protein binding; sequence-specific DNA binding; transcription factor activity Biological Process: positive regulation of transcription from RNA polymerase II promoter; regulation of transcription from RNA polymerase II promoter; rhythmic process; transcription, DNA-dependent |
| NCBI Summary: | This gene encodes a member of the PAR (proline and acidic amino acid-rich) subfamily of basic region/leucine zipper (bZIP) transcription factors. It is expressed in a broad range of cells and tissues in adult animals, however, during embryonic development, TEF expression appears to be restricted to the developing anterior pituitary gland, coincident with the appearance of thyroid-stimulating hormone, beta (TSHB). Indeed, TEF can bind to, and transactivate the TSHB promoter. It shows homology (in the functional domains) with other members of the PAR-bZIP subfamily of transcription factors, which include albumin D box-binding protein (DBP), human hepatic leukemia factor (HLF) and chicken vitellogenin gene-binding protein (VBP); VBP is considered the chicken homologue of TEF. Different members of the subfamily can readily form heterodimers, and share DNA-binding, and transcriptional regulatory properties. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012] |
| UniProt Code: | Q10587 |
| NCBI GenInfo Identifier: | 51338730 |
| NCBI Gene ID: | 7008 |
| NCBI Accession: | Q10587.3 |
| UniProt Secondary Accession: | Q10587,Q15729, Q7Z3J7, Q8IU94, Q96TG4, B0QYS8, B2RC22 |
| UniProt Related Accession: | Q10587 |
| Molecular Weight: | 30,635 Da |
| NCBI Full Name: | Thyrotroph embryonic factor |
| NCBI Synonym Full Names: | thyrotrophic embryonic factor |
| NCBI Official Symbol: | TEFÂ Â |
| NCBI Protein Information: | thyrotroph embryonic factor |
| UniProt Protein Name: | Thyrotroph embryonic factor |
| Protein Family: | Transcription factor |
| UniProt Gene Name: | TEFÂ Â |
| UniProt Entry Name: | TEF_HUMAN |
