The TDP-43 Polyclonal Antibody (CAB14789) is specifically designed for research involving TDP-43, a nuclear protein associated with several neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD). This antibody, produced using rabbits as a host, exhibits high reactivity with human samples and has been validated for use in Western blot applications.TDP-43, or TAR DNA-binding protein 43, is involved in RNA processing and regulation, making it a key player in gene expression and cellular function.
Dysregulation of TDP-43 has been implicated in the pathogenesis of neurodegenerative disorders, highlighting its importance in understanding disease mechanisms.By targeting the TDP-43 protein, researchers can gain insights into its expression levels, subcellular localization, and post-translational modifications in various cell types. This antibody is a valuable tool for investigations in neurobiology, neuropathology, and drug discovery, offering a deeper understanding of TDP-43 biology and its implications for neurological diseases.
Product Name:
DP1/TFDP1 Rabbit Polyclonal Antibody
SKU:
CAB14789
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-290 of human DP1/DP1/TFDP1 (NP_009042.1).
This gene encodes a member of a family of transcription factors that heterodimerize with E2F proteins to enhance their DNA-binding activity and promote transcription from E2F target genes. The encoded protein functions as part of this complex to control the transcriptional activity of numerous genes involved in cell cycle progression from G1 to S phase. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 1, 15, and X.
Purification Method:
Affinity purification
Gene ID:
7027
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Immunohistochemistry analysis of paraffin-embedded rat testis using DP1/TFDP1 Rabbit pAb (CAB14789) at dilution of 1:100 (40x lens).Perform microwave antigen retrieval with 10 mM PBS buffer pH 7.2 before commencing with IHC staining protocol.
