The TGF-Beta 1 Monoclonal Antibody (CAB21244) is a valuable tool for researchers studying Transforming Growth Factor-Beta 1, a key cytokine involved in cell growth, differentiation, and immune response regulation. This antibody, produced using hybridoma technology, specifically targets TGF-Beta 1 and is validated for use in various applications including ELISA, Flow Cytometry, and Immunohistochemistry.TGF-Beta 1 plays a critical role in various biological processes, including tissue repair, immune tolerance, and cancer progression.
Research into TGF-Beta 1 signaling pathways and its effects on cell behavior can provide insights into diseases such as fibrosis, autoimmune disorders, and cancer. The TGF-Beta 1 Monoclonal Antibody allows for precise detection and analysis of TGF-Beta 1 expression in different cell types, enabling researchers to further understand its function and potential therapeutic applications.
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate a latency-associated peptide (LAP) and a mature peptide, and is found in either a latent form composed of a mature peptide homodimer, a LAP homodimer, and a latent TGF-beta binding protein, or in an active form consisting solely of the mature peptide homodimer. The mature peptide may also form heterodimers with other TGFB family members. This encoded protein regulates cell proliferation, differentiation and growth, and can modulate expression and activation of other growth factors including interferon gamma and tumor necrosis factor alpha. This gene is frequently upregulated in tumor cells, and mutations in this gene result in Camurati-Engelmann disease.
Purification Method:
Affinity purification
Gene ID:
7040
Clone Number:
ARC5123-07
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of lysates from K-562 cells, using TGF beta 1 Rabbit mAb (CAB21244) at 1:10000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
