The THOC6 Polyclonal Antibody (CAB17766) is a valuable tool for researchers studying THOC6, a key protein involved in mRNA processing and transport. This antibody, raised in rabbits, is highly specific to human samples and is validated for use in Western blot applications. By binding to the THOC6 protein, this antibody enables researchers to analyze its expression and localization in various cell types, making it ideal for studies in molecular biology and gene regulation.
THOC6, a component of the TREX complex, plays a crucial role in mRNA export from the nucleus to the cytoplasm, essential for proper gene expression. Dysregulation of THOC6 has been linked to various diseases, including cancer and neurodevelopmental disorders. Investigating the function and regulation of THOC6 is important for understanding its role in these conditions and may lead to the development of potential therapeutic interventions.
Product Name:
THOC6 Rabbit Polyclonal Antibody
SKU:
CAB17766
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 50-150 of human THOC6 (NP_077315.2).
This gene encodes a subunit of the multi-protein THO complex, which is involved in coordination between transcription and mRNA processing. The THO complex is a component of the TREX (transcription/export) complex, which is involved in transcription and export of mRNAs. A missense mutation in this gene is associated with a neurodevelopmental disorder called Beaulieu-Boycott-Innes syndrome.
Purification Method:
Affinity purification
Gene ID:
79228
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using THOC6 Rabbit pAb (CAB17766) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.
