The TM4SF1 Monoclonal Antibody (PACO04259) is a valuable tool for researchers studying TM4SF1, a transmembrane protein implicated in various cellular processes, including cell adhesion, migration, and signaling. This antibody, produced using hybridoma technology, specifically targets human samples and has been validated for use in immunohistochemistry and flow cytometry applications. It binds to the TM4SF1 protein, enabling precise detection and analysis in different cell types, making it suitable for studies in cancer biology and cell biology.TM4SF1, also known as transmembrane 4 L six family member 1, is involved in promoting tumor growth, invasion, and metastasis in various cancer types, making it a potential target for cancer therapy development.
Additionally, TM4SF1 has been implicated in modulating immune responses and inflammation, suggesting its importance in autoimmune diseases and chronic inflammatory conditions. Investigating the function of TM4SF1 is crucial for unraveling its role in disease progression and identifying potential therapeutic strategies targeting this protein.
Antibody Name:
TM4SF1 Antibody
Antibody SKU:
PACO04259
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
IHC:1:100-1:300
Species Reactivity:
Human, Mouse
Immunogen:
synthesized peptide derived from the N-terminal region of human TM4SF1.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Synonyms:
TM4SF1; M3S1; TAAL6; Transmembrane 4 L6 family member 1; Membrane component chromosome 3 surface marker 1; Tumor-associated antigen L6
UniProt Protein Function:
TM4SF1: a multi-pass membrane protein. Member of the transmembrane 4 superfamily, also known as the tetraspanin family. These proteins apparently mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This protein is highly expressed in lung, breast, colon and ovarian carcinomas. It is also present on some normal cells, endothelial cells in particular. Present in high molecular weight complexes in tumor cells.Protein type: Membrane protein, multi-pass; Membrane protein, integralChromosomal Location of Human Ortholog: 3q21-q25Cellular Component: integral to plasma membrane
UniProt Protein Details:
NCBI Summary:
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface antigen and is highly expressed in different carcinomas. [provided by RefSeq, Jul 2008]
