The TMEM38B Polyclonal Antibody (PAC041438) is a valuable tool for researchers studying TMEM38B, a transmembrane protein involved in calcium regulation and homeostasis. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blotting applications. By specifically binding to the TMEM38B protein, this antibody allows for accurate detection and analysis in various cell types, making it ideal for studies focused on calcium signaling pathways, cellular physiology, and disease mechanisms.TMEM38B plays a crucial role in maintaining intracellular calcium levels, influencing processes such as cell proliferation, differentiation, and apoptosis. Dysregulation of TMEM38B has been implicated in various diseases, including cancer, neurodegenerative disorders, and cardiovascular conditions.
By investigating the function and expression of TMEM38B using this antibody, researchers can gain insights into the molecular mechanisms underlying these diseases and identify potential therapeutic targets for intervention.Overall, the TMEM38B Polyclonal Antibody (PAC041438) serves as a valuable tool for exploring the roles of TMEM38B in cellular function and disease pathology. Its high specificity and sensitivity make it a reliable reagent for researchers seeking to expand their understanding of calcium signaling dynamics and develop targeted therapies for conditions associated with aberrant calcium handling.
Western blot. All lanes: TMEM38B antibody at 1.5µg/ml. Lane 1: Mouse thymus tissue. Lane 2: Mouse liver tissue. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 33 kDa. Observed band size: 33 kDa.
Immunohistochemistry of paraffin-embedded human small intestine tissue using PACO41438 at dilution of 1:100.
Immunohistochemistry of paraffin-embedded human kidney tissue using PACO41438 at dilution of 1:100.
Background:
Monovalent cation channel required for maintenance of rapid intracellular calcium release. May act as a potassium counter-ion channel that functions in synchronization with calcium release from intracellular stores (By similarity).
Synonyms:
Trimeric intracellular cation channel type B (TRIC-B) (TRICB) (Transmembrane protein 38B), TMEM38B, C9orf87
UniProt Protein Function:
TMEM38B: Monovalent cation channel required for maintenance of rapid intracellular calcium release. May act as a potassium counter-ion channel that functions in synchronization with calcium release from intracellular stores. Belongs to the TMEM38 family.Protein type: Membrane protein, integral; Membrane protein, multi-passChromosomal Location of Human Ortholog: 9q31.2Cellular Component: integral to membrane; nuclear membrane; nucleus; sarcoplasmic reticulum membraneMolecular Function: potassium channel activityDisease: Osteogenesis Imperfecta, Type Xiv
UniProt Protein Details:
NCBI Summary:
This gene encodes an intracellular monovalent cation channel that functions in maintenance of intracellular calcium release. Mutations in this gene may be associated with autosomal recessive osteogenesis. [provided by RefSeq, Oct 2012]
