---The TMX3 Polyclonal Antibody (PACO39326) is a valuable tool for researchers studying TMX3, a protein involved in protein folding and quality control in the endoplasmic reticulum. This antibody, generated in rabbits, exhibits high specificity and sensitivity towards human samples, making it an excellent choice for studies in the fields of cell biology and molecular biology.TMX3 is known to play a crucial role in maintaining protein homeostasis by facilitating the correct folding and assembly of proteins within the ER. Dysregulation of TMX3 has been linked to various diseases, including neurodegenerative disorders and cancer, highlighting its importance in cellular function.
By targeting TMX3 with this antibody, researchers can gain insights into the role of TMX3 in disease pathogenesis and potentially identify new therapeutic targets for intervention. The use of this antibody in techniques such as Western blotting allows for the accurate detection and quantification of TMX3 levels in different cell types, paving the way for further research into the function of TMX3 in health and disease.
Antibody Name:
TMX3 Antibody (PACO39326)
Antibody SKU:
PACO39326
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:10000, IHC:1:20-1:200
Species Reactivity:
Human
Immunogen:
Recombinant Human Protein disulfide-isomerase TMX3 protein (25-195AA)
Immunohistochemistry of paraffin-embedded human testis tissue using PACO39326 at dilution of 1:100.
Background:
Probable disulfide isomerase, which participates in the folding of proteins containing disulfide bonds. May act as a dithiol oxidase.
Synonyms:
Protein disulfide-isomerase TMX3 (EC 5.3.4.1) (Thioredoxin domain-containing protein 10) (Thioredoxin-related transmembrane protein 3), TMX3, KIAA1830 TXNDC10
UniProt Protein Function:
TXNDC10: Probable disulfide isomerase, which participates in the folding of proteins containing disulfide bonds. May act as a dithiol oxidase. Belongs to the protein disulfide isomerase family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: EC 5.3.4.1; Isomerase; Membrane protein, integralChromosomal Location of Human Ortholog: 18q22Cellular Component: cell surface; endoplasmic reticulum membrane; plasma membrane; platelet alpha granule membraneMolecular Function: protein binding; protein disulfide isomerase activity; thiol oxidase activityBiological Process: peptidyl-cysteine oxidation; platelet degranulation; protein folding
