The TNFR2/TNFRSF1B Monoclonal Antibody (CAB19127) is a high-quality antibody developed for reliable detection and analysis of target proteins. This antibody, developed using rabbit monoclonal technology, demonstrates high specificity and sensitivity in detecting TNF receptor II in human samples.TNF receptor II, also known as TNFRSF1B, is an important mediator of the TNF signaling pathway, which plays a central role in the immune system's response to infections and inflammatory diseases. By targeting TNF receptor II, researchers can gain insights into the mechanisms underlying various diseases, including autoimmune disorders, cancer, and chronic inflammatory conditions.
This antibody is validated for use in WB, ELISA applications and has demonstrated reactivity against Human samples.
Product Name:
TNFR2/TNFRSF1B Monoclonal Antibody
SKU:
CAB19127
Size:
20μL, 100μL
Reactivity:
Human
Clone Number:
ARC0397
Conjugate:
Unconjugated
Immunogen:
Synthetic peptide. This information is considered to be commercially sensitive.
Cell Membrane, Secreted, Single-Pass Type I Membrane Protein.
Calculated MW:
48kDa
Observed MW:
68kDa
The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein and TNF-receptor 1 form a heterocomplex that mediates the recruitment of two anti-apoptotic proteins, c-IAP1 and c-IAP2, which possess E3 ubiquitin ligase activity. The function of IAPs in TNF-receptor signalling is unknown, however, c-IAP1 is thought to potentiate TNF-induced apoptosis by the ubiquitination and degradation of TNF-receptor-associated factor 2, which mediates anti-apoptotic signals. Knockout studies in mice also suggest a role of this protein in protecting neurons from apoptosis by stimulating antioxidative pathways.
Purification Method
Affinity purification
Gene ID
7133
RRID
AB_2862620
Buffer Information
Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol and 0.05% BSA, preserved with proclin300 or sodium azide, pH 7.3.
Western blot analysis of various lysates using TNFR2/TNFRSF1B Rabbit mAb (CAB19127) at 1:1000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (AbGn00020). Exposure time: 10s.
