RANKL Rabbit Polyclonal Antibody (CAB2550)
- SKU:
- CAB2550
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Developmental Biology
Description
Product Name: | RANKL Rabbit Polyclonal Antibody |
SKU: | CAB2550 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 210-309 of human RANKL (NP_003692.1). |
Sequence: | QDGF YYLY ANIC FRHH ETSG DLAT EYLQ LMVY VTKT SIKI PSSH TLMK GGST KYWS GNSE FHFY SINV GGFF KLRS GEEI SIEV SNPS LLDP DQDA TYFG |
Tested Applications: | WB IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 IF/ICC,1:50 - 1:200 |
Synonyms: | ODF; OPGL; sOdf; CD254; OPTB2; RANKL; TNLG6B; TRANCE; hRANKL2 |
Positive Sample: | A-549,K-562,Raji,SGC-7901,Rat lung,SP2/0,A-549,K-562,Raji,SGC-7901 |
Conjugate: | Unconjugated |
Cellular Localization: | Cell membrane, Cytoplasm, Secreted, Single-pass type II membrane protein, Single-pass type II membrane protein. |
Calculated MW: | 35kDa |
Observed MW: | 31kDa/45kDa |
This gene encodes a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. This protein was shown to be a dentritic cell survival factor and is involved in the regulation of T cell-dependent immune response. T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. This protein was shown to activate antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor-associated factor (TRAF) 6, which indicated this protein may have a role in the regulation of cell apoptosis. Targeted disruption of the related gene in mice led to severe osteopetrosis and a lack of osteoclasts. The deficient mice exhibited defects in early differentiation of T and B lymphocytes, and failed to form lobulo-alveolar mammary structures during pregnancy. Two alternatively spliced transcript variants have been found.
Purification Method: | Affinity purification |
Gene ID: | 8600 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |