p53 Rabbit Polyclonal Antibody (CAB3185)
- SKU:
- CAB3185
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Death
Frequently bought together:
Description
Product Name: | p53 Rabbit Polyclonal Antibody |
SKU: | CAB3185 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1-393 of human p53 (NP_000537.3). |
Sequence: | MEEP QSDP SVEP PLSQ ETFS DLWK LLPE NNVL SPLP SQAM DDLM LSPD DIEQ WFTE DPGP DEAP RMPE AAPP VAPA PAAP TPAA PAPA PSWP LSSS VPSQ KTYQ GSYG FRLG FLHS GTAK SVTC TYSP ALNK MFCQ LAKT CPVQ LWVD STPP PGTR VRAM AIYK QSQH MTEV VRRC PHHE RCSD SDGL APPQ HLIR VEGN LRVE YLDD RNTF RHSV VVPY EPPE VGSD CTTI HYNY MCNS SCMG GMNR RPIL TIIT LEDS SGNL LGRN SFEV RVCA CPGR DRRT EEEN LRKK GEPH HELP PGST KRAL PNNT SSSP QPKK KPLD GEYF TLQI RGRE RFEM FREL NEAL ELKD AQAG KEPG GSRA HSSH LKSK KGQS TSRH KKLM FKTE GPDS D |
Tested Applications: | WB IHC-P IF/ICC IP ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 IHC-P,1:50 - 1:200 IF/ICC,1:50 - 1:200 IP,0.5μg-4μg antibody for 200μg-400μg extracts of whole cells |
Synonyms: | P53; BCC7; LFS1; BMFS5; TRP53; p53 |
Positive Sample: | U-251MG,MCF7,293T,NIH/3T3 |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasm, Endoplasmic reticulum, Mitochondrion matrix, Nucleus, PML body. |
Calculated MW: | 44kDa |
Observed MW: | 53kDa |
This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons from identical transcript variants (PMIDs: 12032546, 20937277).
Purification Method: | Affinity purification |
Gene ID: | 7157 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |