The TRAF1 Polyclonal Antibody (CAB0150) is specifically designed for research involving TRAF1, a key regulator of immune signaling pathways. This antibody, produced in rabbits, exhibits high reactivity towards human samples and is validated for use in Western blot applications. By targeting the TRAF1 protein, this antibody allows for precise detection and analysis in various cell types, making it an ideal tool for studies in immunology and cancer research.TRAF1, also known as tumor necrosis factor receptor-associated factor 1, plays a crucial role in modulating immune responses and inflammatory pathways.
Its involvement in regulating cell survival and apoptosis makes it a valuable target for research into various diseases, including cancer and autoimmune disorders. Understanding the function of TRAF1 is essential for developing targeted therapies that can manipulate immune responses in these disease contexts.Overall, the TRAF1 Polyclonal Antibody (CAB0150) offers researchers a reliable tool for investigating the role of TRAF1 in immune regulation and disease pathogenesis, ultimately advancing our understanding of immunology and paving the way for new therapeutic interventions.
Product Name:
TRAF1 Rabbit Polyclonal Antibody
SKU:
CAB0150
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 217-416 of human TRAF1 (NP_005649.1).
cytoplasm, cytoplasmic side of plasma membrane, cytosol
Calculated MW:
46kDa
Observed MW:
50kDa
The protein encoded by this gene is a member of the TNF receptor (TNFR) associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from various receptors of the TNFR superfamily. This protein and TRAF2 form a heterodimeric complex, which is required for TNF-alpha-mediated activation of MAPK8/JNK and NF-kappaB. The protein complex formed by this protein and TRAF2 also interacts with inhibitor-of-apoptosis proteins (IAPs), and thus mediates the anti-apoptotic signals from TNF receptors. The expression of this protein can be induced by Epstein-Barr virus (EBV). EBV infection membrane protein 1 (LMP1) is found to interact with this and other TRAF proteins; this interaction is thought to link LMP1-mediated B lymphocyte transformation to the signal transduction from TNFR family receptors. Three transcript variants encoding two different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
7185
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using TRAF1 Rabbit pAb (CAB0150) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
