The TRIM21/SS-A Monoclonal Antibody (CAB22724) is a high-quality antibody developed for reliable detection and analysis of target proteins. This monoclonal antibody was developed using advanced techniques to ensure high specificity and sensitivity in detecting Trim21 in various biological samples. Trim21, also known as Ro52, plays a crucial role in the immune system by targeting intracellular pathogens for degradation. It is also implicated in the development of autoimmune conditions, making it a promising target for therapeutic interventions.
This antibody is validated for use in WB, ELISA applications and has demonstrated reactivity against Human samples.
Product Name:
TRIM21/SS-A Monoclonal Antibody
SKU:
CAB22724
Size:
20μL, 100μL
Reactivity:
Human
Clone Number:
ARC57363
Conjugate:
Unconjugated
Immunogen:
Synthetic peptide. This information is considered to be commercially sensitive.
This gene encodes a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The encoded protein is part of the RoSSA ribonucleoprotein, which includes a single polypeptide and one of four small RNA molecules. The RoSSA particle localizes to both the cytoplasm and the nucleus. RoSSA interacts with autoantigens in patients with Sjogren syndrome and systemic lupus erythematosus. Alternatively spliced transcript variants for this gene have been described but the full-length nature of only one has been determined.
Purification Method
Affinity purification
Gene ID
6737
Buffer Information
Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.09% Sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of lysates from HT-1080 cells, using [KO Validated] TRIM21/SS-A Rabbit mAb (CAB22724) at 1:2000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (AbGn00020). Exposure time: 60s.
Western blot analysis of lysates from wild type (WT) and TRIM21/SS-A knockout (KO) 293T cells, using [KO Validated] TRIM21/SS-A Rabbit mAb (CAB22724) at 1:2000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (AbGn00020). Exposure time: 60s.
