The TXNIP Polyclonal Antibody (PAC020801) is a crucial tool for researchers studying the role of TXNIP in various cellular processes. TXNIP, also known as thioredoxin-interacting protein, is involved in the regulation of cellular redox balance and has been implicated in various diseases, including diabetes and cancer.This antibody, generated in rabbits, exhibits high specificity and sensitivity towards human TXNIP, making it an ideal choice for Western blotting and immunohistochemistry applications. By binding to the TXNIP protein, researchers can accurately detect and analyze its expression levels in different cell types and tissues, providing valuable insights into its function.
Given TXNIP's involvement in metabolic disorders and cancer progression, understanding its mechanisms of action is crucial for developing targeted therapies and diagnostic strategies. The use of the TXNIP Polyclonal Antibody in research studies will undoubtedly contribute to advancing our knowledge of TXNIP's role in health and disease.
Antibody Name:
TXNIP Antibody (PACO20801)
Antibody SKU:
PACO20801
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:10000, IHC:1:30-1:150
Species Reactivity:
Human, Mouse, Rat
Immunogen:
Synthetic peptide of human TXNIP
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using PACO20801(TXNIP Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest. Required for the maturation of natural killer cells. Acts as a suppressor of tumor cell growth. Inhibits the proteasomal degradation of DDIT4, and thereby contributes to the inhibition of the mammalian target of rapamycin complex 1 (mTORC1).
Synonyms:
thioredoxin interacting protein
UniProt Protein Function:
May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest. Required for the maturation of natural killer cells. Acts as a suppressor of tumor cell growth. Inhibits the proteasomal degradation of DDIT4, and thereby contributes to the inhibition of the mammalian target of rapamycin complex 1 (mTORC1).
NCBI Summary:
This gene encodes a thioredoxin-binding protein that is a member of the alpha arrestin protein family. Thioredoxin is a thiol-oxidoreductase that is a major regulator of cellular redox signaling which protects cells from oxidative stress. This protein inhibits the antioxidative function of thioredoxin resulting in the accumulation of reactive oxygen species and cellular stress. This protein also functions as a regulator of cellular metabolism and of endoplasmic reticulum (ER) stress. This protein may also function as a tumor suppressor. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]
