The TXNRD3 Polyclonal Antibody (PAC013006) is a valuable tool for researchers studying TXNRD3, a key enzyme involved in redox regulation and cellular defense against oxidative stress. This antibody, raised in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blotting applications. By specifically binding to the TXNRD3 protein, this antibody enables accurate detection and analysis in various cell types, making it an ideal choice for studies in antioxidant defense mechanisms, cancer biology, and neurodegenerative diseases.TXNRD3, also known as thioredoxin reductase 3, plays a crucial role in maintaining cellular redox balance and protecting against oxidative damage. Dysregulation of TXNRD3 has been implicated in various diseases, including cancer, neurodegenerative disorders, and cardiovascular diseases.
Investigating the function and regulation of TXNRD3 is essential for understanding its role in disease pathogenesis and for developing targeted therapies that exploit its redox-modulating properties.Overall, the TXNRD3 Polyclonal Antibody is a valuable tool for researchers seeking to elucidate the molecular mechanisms underlying oxidative stress-related diseases and for those aiming to identify novel therapeutic strategies based on TXNRD3 modulation. Its high specificity and sensitivity make it an essential component of any research study focused on redox biology and related pathologies.
TXNRD3: Displays thioredoxin reductase, glutaredoxin and glutathione reductase activities. Catalyzes disulfide bond isomerization. Promotes disulfide bond formation between GPX4 and various sperm proteins and may play a role in sperm maturation by promoting formation of sperm structural components. Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.Protein type: EC 1.8.1.9; OxidoreductaseChromosomal Location of Human Ortholog: 3q21.3
UniProt Protein Details:
NCBI Summary:
This gene encodes a member of the family of pyridine nucleotide oxidoreductases. This protein catalyzes the reduction of thioredoxin, and is implicated in the defense against oxidative stress. It contains a selenocysteine (Sec) residue (which is essential for catalytic activity), encoded by a UGA codon, at the penultimate C-terminal position. The 3' UTR of Sec-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]
