The TYW1B Antibody (PACO13008) is a high-quality polyclonal antibody designed for research involving TYW1B, a protein involved in tRNA modification. This antibody, raised in rabbits, is highly specific and reactive with human samples, making it a valuable tool for studying the role of TYW1B in various cellular processes.TYW1B is known to play a crucial role in the modification of tRNAs, which are essential for protein synthesis in cells. By targeting TYW1B with this antibody, researchers can investigate its function and impact on gene expression regulation. The antibody is validated for use in Western blot applications, allowing for easy detection and analysis of TYW1B in different cell types.
This antibody is particularly suitable for studies in molecular biology, cell biology, and RNA biology. Understanding the role of TYW1B in tRNA modification has implications for a wide range of research areas, including protein translation, gene expression regulation, and potential therapeutic interventions in diseases related to tRNA dysfunction. Researchers can rely on the TYW1B Antibody (PACO13008) to advance their research and deepen their understanding of this important protein.
tRNA-yW synthesizing protein 1 homolog B (non-protein coding);TYW1B;MGC87315;NCRNA00069;RSAFD2 ;
UniProt Protein Function:
TYW1B: Probable component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Belongs to the TYW1 family.Protein type: EC 4.1.3.44Chromosomal Location of Human Ortholog: 7q11.23Molecular Function: FMN binding; iron ion binding; 4 iron, 4 sulfur cluster binding; lyase activity; oxidoreductase activityBiological Process: tRNA processing
UniProt Protein Details:
NCBI Summary:
Wybutosine (yW) is a hypermodified guanosine found in phenylalanine tRNA adjacent to the anticodon that stabilizes codon-anticodon interactions in the ribosome. In yeast, the homolog of this gene is essential for the synthesis of wybutosine. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]
