Description
UTS2B Antibody (PACO20844)
The UTS2B Polyclonal Antibody (PAC020844) is a valuable tool for researchers studying the Urotensin-2B (UTS2B) protein, which is involved in various physiological processes such as vasoconstriction and cell proliferation. This antibody, raised in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications.UTS2B is a peptide hormone that plays a key role in cardiovascular function and has been implicated in the pathogenesis of cardiovascular diseases. Research into the function and regulation of UTS2B is important for understanding its potential as a therapeutic target for conditions such as hypertension, heart failure, and atherosclerosis.
By utilizing the UTS2B Polyclonal Antibody, researchers can detect and analyze the UTS2B protein in different cell types, enabling further investigation into its physiological role and potential therapeutic applications. This antibody is an essential tool for studies in cardiovascular physiology and drug development aimed at targeting UTS2B for the treatment of cardiovascular disorders.
| Antibody Name: | UTS2B Antibody (PACO20844) |
| Antibody SKU: | PACO20844 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:5000, WB:1:500-1:2000, IHC:1:25-1:100 |
| Species Reactivity: | Human |
| Immunogen: | Synthetic peptide of human UTS2B |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Gel: 12%SDS-PAGE,Lysate: 40 µg,Lane 1-6: A431 cells, Human liver cancer tissue, Lovo cells, PC3 cells, Human placenta tissue, 293T cells,Primary antibody: PACO20844(UTS2B Antibody) at dilution 1/200 dilution,Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution,Exposure time: 30 seconds. |
 | The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO20844(UTS2B Antibody) at dilution 1/35, on the right is treated with synthetic peptide. (Original magnification: x200). |
| Background: | Potent vasoconstrictor.Human Urotensin II is composed of only 11 amino acid, residues, while fish and frog Urotensin II possess 12 and 13 amino acid, residues, respectively (2). Human Urotensin II is found within both vascular and cardiac tissue, including coronary atheroma, and effectively constricts isolated arteries from nonhuman primates (3). Urotensin II may act as an autocrine and/or paracrine hormone rather than as a circulating hormone, by playing an important role in the development of ventricular hypertrophy induced by chronic hypoxia (4). |
| Synonyms: | urotensin 2B |
| UniProt Protein Function: | UTS2D: Potent vasoconstrictor. Belongs to the urotensin-2 family. |
| UniProt Protein Details: | Protein type:Secreted, signal peptide; Secreted Chromosomal Location of Human Ortholog: 3q28 Cellular Component: extracellular region |
| UniProt Code: | Q765I0 |
| NCBI GenInfo Identifier: | 212287929 |
| NCBI Gene ID: | 257313 |
| NCBI Accession: | Q765I0.2 |
| UniProt Secondary Accession: | Q765I0,Q2M1Z2, B3KQY8, D3DNW1, |
| UniProt Related Accession: | Q765I0 |
| Molecular Weight: | 13,749 Da |
| NCBI Full Name: | Urotensin-2B |
| NCBI Synonym Full Names: | urotensin 2B |
| NCBI Official Symbol: | UTS2BÂ Â |
| NCBI Official Synonym Symbols: | U2B; URP; UTS2DÂ Â |
| NCBI Protein Information: | urotensin-2B |
| UniProt Protein Name: | Urotensin-2B |
| UniProt Synonym Protein Names: | Urotensin II-related peptide; Urotensin IIB; U-IIB; UIIB; Urotensin-2 domain-containing protein |
| Protein Family: | Prepro-urotensin |
| UniProt Gene Name: | UTS2BÂ Â |
| UniProt Entry Name: | UTS2B_HUMAN |
