The VGF Polyclonal Antibody (PAC020853) is a vital tool for researchers investigating the role of VGF, a neuropeptide involved in regulating energy balance and metabolism. Produced in rabbits, this antibody is specifically designed for use with human samples and is validated for Western blot applications. It targets the VGF protein, allowing for precise detection and analysis in a variety of cell types, making it ideal for studies in neuroscience and metabolic disorders.VGF, also known as NERP-1, is a peptide that has been linked to numerous physiological processes, including appetite regulation, mood control, and synaptic plasticity.
Its role in metabolic regulation and neuroprotection makes it a promising target for research into conditions such as obesity, diabetes, and neurodegenerative diseases. Understanding the functions of VGF is essential for advancing the development of therapies aimed at modulating energy balance and cognitive function.
Antibody Name:
VGF Antibody (PACO20853)
Antibody SKU:
PACO20853
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:5000, IHC:1:25-1:100
Species Reactivity:
Human, Rat
Immunogen:
Synthetic peptide of human VGF
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using PACO20853(VGF Antibody) at dilution 1/35, on the right is treated with synthetic peptide. (Original magnification: x200).
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO20853(VGF Antibody) at dilution 1/35, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
This gene is specifically expressed in a subpopulation of neuroendocrine cells, and is upregulated by nerve growth factor. The structural organization of this gene is similar to that of the rat gene, and both the translated and the untranslated regions show a high degree of sequence similarity to the rat gene. The encoded secretory protein also shares similarities with the secretogranin/chromogranin family, however, its exact function is not known.
Synonyms:
VGF nerve growth factor inducible
UniProt Protein Function:
VGF: May be involved in the regulation of cell-cell interactions or in synatogenesis during the maturation of the nervous system.
UniProt Protein Details:
Protein type:Secreted, signal peptide; Secreted
Chromosomal Location of Human Ortholog: 7q22.1
Cellular Component: extracellular space; transport vesicle; cytoplasmic vesicle
Biological Process: response to dietary excess; generation of precursor metabolites and energy; response to cAMP; ovarian follicle development; insulin secretion; sexual reproduction; defense response to bacterium; response to cold; glucose homeostasis; response to insulin stimulus
NCBI Summary:
This gene is specifically expressed in a subpopulation of neuroendocrine cells, and is upregulated by nerve growth factor. The structural organization of this gene is similar to that of the rat gene, and both the translated and the untranslated regions show a high degree of sequence similarity to the rat gene. The encoded secretory protein also shares similarities with the secretogranin/chromogranin family, however, its exact function is not known. [provided by RefSeq, Jul 2008]
