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Anti-VGF Antibody (CAB14795)

SKU:
CAB14795
Product Type:
Antibody
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Signal Transduction
€139 - €419
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Description

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Antibody Name:Anti-VGF Antibody
Antibody SKU:CAB14795
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 466-615 of human VGF (NP_003369.2).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Rat
Positive Samples:Rat brain
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 466-615 of human VGF (NP_003369.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:ADDV VSII EEVE EKRK RKKN APPE PVPP PRAA PAPT HVRS PQPP PPAP APAR DELP DWNE VLPP WDRE EDEV YPPG PYHP FPNY IRPR TLQP PSAL RRRH YHHA LPPS RHYP GREA QARR AQEE AEAE ERRL QEQE ELEN YIEH VLLR RP
Gene ID:7425
Uniprot:O15240
Cellular Location:Cytoplasmic vesicle, Secreted, secretory vesicle
Calculated MW:67kDa
Observed MW:70kDa
Synonyms:VGF, SCG7, SgVII
Background:This gene is specifically expressed in a subpopulation of neuroendocrine cells, and is upregulated by nerve growth factor. The structural organization of this gene is similar to that of the rat gene, and both the translated and the untranslated regions show a high degree of sequence similarity to the rat gene. The encoded secretory protein also shares similarities with the secretogranin/chromogranin family, however, its exact function is not known.
UniProt Protein Function:VGF: May be involved in the regulation of cell-cell interactions or in synatogenesis during the maturation of the nervous system.
UniProt Protein Details:

Protein type:Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 7q22.1

Cellular Component: extracellular space; transport vesicle; cytoplasmic vesicle

Molecular Function:neuropeptide hormone activity; growth factor activity

Biological Process: response to dietary excess; generation of precursor metabolites and energy; response to cAMP; ovarian follicle development; insulin secretion; sexual reproduction; defense response to bacterium; response to cold; glucose homeostasis; response to insulin stimulus

NCBI Summary:This gene is specifically expressed in a subpopulation of neuroendocrine cells, and is upregulated by nerve growth factor. The structural organization of this gene is similar to that of the rat gene, and both the translated and the untranslated regions show a high degree of sequence similarity to the rat gene. The encoded secretory protein also shares similarities with the secretogranin/chromogranin family, however, its exact function is not known. [provided by RefSeq, Jul 2008]
UniProt Code:O15240
NCBI GenInfo Identifier:206729943
NCBI Gene ID:7425
NCBI Accession:O15240.2
UniProt Secondary Accession:O15240,Q9UDW8,
UniProt Related Accession:O15240
Molecular Weight:67,258 Da
NCBI Full Name:Neurosecretory protein VGF
NCBI Synonym Full Names:VGF nerve growth factor inducible
NCBI Official Symbol:VGF  
NCBI Protein Information:neurosecretory protein VGF; neuro-endocrine specific protein VGF
UniProt Protein Name:Neurosecretory protein VGF
Protein Family:Neurosecretory protein
UniProt Gene Name:VGF  
UniProt Entry Name:VGF_HUMAN
Anti-VGF Antibody (CAB14795)Western blot analysis of extracts of rat brain, using VGF antibody (CAB14795) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 90s.

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