The VPS36 Polyclonal Antibody (PAC020866) is a valuable tool for researchers studying VPS36, a key protein involved in endosomal sorting and trafficking. This antibody, generated in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By specifically binding to VPS36, this antibody enables precise detection and analysis of the protein in a variety of cell types, making it an essential component for studies in cell biology and molecular biology.VPS36 is essential for the sorting of cargo proteins into multivesicular bodies, a process critical for maintaining cellular homeostasis and regulating signaling pathways.
Dysregulation of VPS36 has been implicated in various diseases, including neurodegenerative disorders and infectious diseases. Thus, understanding the function of VPS36 is crucial for unraveling the mechanisms underlying these conditions and developing targeted therapies.Overall, the VPS36 Polyclonal Antibody (PAC020866) is a reliable tool for researchers seeking to investigate the role of VPS36 in cellular processes and disease pathogenesis. Its specificity, sensitivity, and versatility make it an invaluable asset for advancing scientific knowledge in the field of cell biology and beyond.
Antibody Name:
VPS36 Antibody (PACO20866)
Antibody SKU:
PACO20866
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:10000, IHC:1:30-1:150
Species Reactivity:
Human, Mouse, Rat
Immunogen:
Synthetic peptide of human VPS36
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using PACO20866(VPS36 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200).
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO20866(VPS36 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
This gene encodes a protein that is a subunit of the endosomal sorting complex required for transport II (ESCRT-II). This protein complex functions in sorting of ubiquitinated membrane proteins during endocytosis. A similar protein complex in rat is associated with RNA polymerase elongation factor II.
Synonyms:
vacuolar protein sorting 36 homolog (S. cerevisiae)
