The WNK2 Polyclonal Antibody (PAC020886) is a valuable tool for researchers studying WNK2, a protein kinase involved in regulating ion transport and cell volume. This antibody, generated in rabbits, demonstrates high reactivity with human samples and is validated for use in Western blot applications. By specifically binding to the WNK2 protein, this antibody enables detection and analysis in various cell types, making it ideal for studies in physiology, neuroscience, and related fields.WNK2, known for its role in regulating ion channels and transporters, is implicated in numerous physiological processes, including blood pressure regulation and cell growth.
Research on WNK2 is particularly relevant to understanding diseases such as hypertension, kidney disorders, and neurological conditions. Investigating the functions of WNK2 with the help of this antibody may lead to insights that advance our understanding of these health issues and potentially inform new therapeutic approaches.
The image on the left is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using PACO20886(WNK2 Antibody) at dilution 1/35, on the right is treated with synthetic peptide. (Original magnification: x200).
Gel: 6%SDS-PAGE,Lysate: 40 µg,Lane 1-2: A431 cells, MCF7 cells,Primary antibody: PACO20886(WNK2 Antibody) at dilution 1/200 dilution,Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution,Exposure time: 3 minutes.
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO20886(WNK2 Antibody) at dilution 1/35, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
The protein encoded by this gene is a cytoplasmic serine-threonine kinase that belongs to the protein kinase superfamily. The protein plays an important role in the regulation of electrolyte homeostasis, cell signaling survival, and proliferation. Alternative splicing results in multiple transcript variants.
