The WWOX Antibody (CAB12653) is a high-quality antibody developed for reliable detection and analysis of target proteins. This rabbit-raised antibody is highly reactive with human samples and has been validated for use in Western blot applications. By specifically binding to the WWOX protein, this antibody enables accurate detection and analysis in a variety of cell types, making it ideal for studies in cancer research and genetic disorders.The WWOX gene, also known as WW domain-containing oxidoreductase, is a tumor suppressor gene that is frequently altered in various types of cancers. Its role in maintaining genomic stability and regulating cell growth makes it a promising target for understanding cancer development and identifying potential therapeutic interventions.
This antibody is validated for use in WB, ELISA applications and has demonstrated reactivity against Human, Mouse, Rat samples.
Product Name:
WWOX Antibody
SKU:
CAB12653
Size:
20μL, 100μL
Reactivity:
Human, Mouse, Rat
Conjugate:
Unconjugated
Immunogen:
Recombinant protein (or fragment).This information is considered to be commercially sensitive.
This gene encodes a member of the short-chain dehydrogenases/reductases (SDR) protein family. This gene spans the FRA16D common chromosomal fragile site and appears to function as a tumor suppressor gene. Expression of the encoded protein is able to induce apoptosis, while defects in this gene are associated with multiple types of cancer. Disruption of this gene is also associated with autosomal recessive spinocerebellar ataxia 12. Disruption of a similar gene in mouse results in impaired steroidogenesis, additionally suggesting a metabolic function for the protein. Alternative splicing results in multiple transcript variants.
Purification Method
Affinity purification
Gene ID
51741
RRID
AB_2759499
Buffer Information
Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using WWOX Rabbit pAb (CAB12653) at 1:3000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (AbGn00020). Exposure time: 10s.
