The ZC3H13 Polyclonal Antibody (PACO01719) is a valuable tool for researchers studying ZC3H13, a key player in RNA metabolism and gene expression regulation. This antibody, produced in rabbits, exhibits high specificity and sensitivity for detecting ZC3H13 in human samples, making it a reliable choice for Western blot applications. By targeting the ZC3H13 protein, researchers can effectively investigate its role in various cellular processes and pathways, particularly in the fields of RNA biology and cancer research.ZC3H13, also known as Zinc Finger CCCH-Type Containing 13, is involved in mRNA processing and stability, influencing gene expression dynamics and cellular functions.
Dysregulation of ZC3H13 has been linked to various diseases, making it a promising therapeutic target for conditions such as cancer and neurological disorders. By elucidating the functions and mechanisms of ZC3H13, researchers can uncover new insights into disease pathogenesis and potentially develop novel treatment strategies aimed at correcting aberrant gene expression.
Antibody Name:
ZC3H13 Antibody
Antibody SKU:
PACO01719
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
WB:1:500-1:2000
Species Reactivity:
Human, Mouse
Immunogen:
synthesized peptide derived from the C-terminal region of human ZC3H13.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Synonyms:
ZC3H13; KIAA0853; Zinc finger CCCH domain-containing protein 13
UniProt Protein Function:
Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (PubMed:29507755). Acts as a key regulator of m6A methylation by promoting m6A methylation of mRNAs at the 3'-UTR (). Controls embryonic stem cells (ESCs) pluripotency via its role in m6A methylation (). In the WMM complex, anchors component of the MACOM subcomplex in the nucleus (). Also required for bridging WTAP to the RNA-binding component RBM15 (RBM15 or RBM15B) ().
