Based on the information provided in the URL, here is a product description for the ZNF473 Antibody (PAC020951):The ZNF473 Polyclonal Antibody (PAC020951) is a powerful tool for researchers studying ZNF473, a zinc finger protein involved in gene regulation and cellular processes. This antibody, produced in rabbits, exhibits high specificity and sensitivity towards human samples, making it an excellent choice for various research applications.ZNF473 is known to play a role in transcriptional regulation and has been implicated in a variety of biological processes, including development, differentiation, and disease pathogenesis. By targeting ZNF473 with this antibody, researchers can accurately detect and analyze the protein in different cell types and experimental settings, providing valuable insights into its function and potential implications in various biological contexts.
Given the diverse roles of ZNF473 in cellular processes, this antibody is an invaluable asset for studies in molecular biology, genetics, and disease research. Its specificity and reliability make it a valuable tool for investigating the function and regulation of ZNF473, offering new opportunities for advancing our understanding of gene expression dynamics and potential therapeutic targets.
Antibody Name:
ZNF473 Antibody (PACO20951)
Antibody SKU:
PACO20951
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:5000, IHC:1:25-1:100
Species Reactivity:
Human
Immunogen:
Synthetic peptide of human ZNF473
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human colorectal cancer tissue using PACO20951(ZNF473 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: x200).
The image on the left is immunohistochemistry of paraffin-embedded Human tonsil tissue using PACO20951(ZNF473 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
Involved in histone 3'-end pre-mRNA processing by associating with U7 snRNP and interacting with SLBP/pre-mRNA complex. Increases histone 3'-end pre-mRNA processing but has no effect on U7 snRNP levels, when overexpressed. Required for cell cycle progression from G1 to S phases.
Synonyms:
zinc finger protein 473
UniProt Protein Function:
ZNF473: Involved in histone 3'-end pre-mRNA processing by associating with U7 snRNP and interacting with SLBP/pre-mRNA complex. Increases histone 3'-end pre-mRNA processing but has no effect on U7 snRNP levels, when overexpressed. Required for cell cycle progression from G1 to S phases. Belongs to the krueppel C2H2-type zinc-finger protein family.Protein type: C2H2-type zinc finger proteinChromosomal Location of Human Ortholog: 19q13.33Cellular Component: Cajal body; nucleoplasmMolecular Function: protein bindingBiological Process: histone mRNA 3'-end processing; histone mRNA metabolic process; termination of RNA polymerase II transcription
UniProt Protein Details:
NCBI Summary:
This gene encodes a member of the Krueppel C2H2-type zinc-finger family of proteins. The encoded protein, a component of the U7 snRNP complex, plays a role in histone 3'-end pre-mRNA processing and may be required for cell cycle progression to S phase. Expression level and methylation status of this gene may be correlated with bone mineral density. [provided by RefSeq, Jul 2016]
